The objective of maintaining the cleanliness of the multi-segment disk amplifier in Shenguang-II (SG-II) is to reduce laser-induced damage for optics. The flow field of clean gas, which is used for the transportation of contaminant particles, is a key factor affecting the cleanliness level in the multi-segment disk amplifier. We developed a gas–solid coupling and three-dimensional flow numerical simulation model. The three-dimensional and two-phase flow model is verified by the flow-field smog experiment and the particle concentration measurement experiment with the 130-disk amplifier in SG-II. By optimizing the boundary conditions with the same flow rate, the multi-inlet vector flow scheme can not only effectively reduce the purging time, but also prevent the reverse diffusion of contaminant particles in the multi-segment disk amplifier and the deposition of contaminant particles on the surface of the Nd:glass.