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1 results

  • 36 - Levels of Analysis in Alzheimer’s Disease Research

  • from Section 12
  • Edited by Kenneth S. Kendler, Virginia Commonwealth University, Josef Parnas, University of Copenhagen, Peter Zachar, Auburn University, Montgomery
  • Book:
    Levels of Analysis in Psychopathology
    Published online:
    02 April 2020
    Print publication:
    02 April 2020, pp 450-456

  • Summary

    Psychiatric disorders can be explained at various levels of analysis. Some models start out with first-person experience, some focus on psychological and sociological factors and some look for answers by studying the brain. These levels of analysis are often defined by subject matter (e.g., life events or brain changes), scientific methods (e.g., interview or brain scan), and claims of causality (e.g., weak environmental effects of life stressors or strong genetic effects in Mendelian disorders). Here I am reviewing progress in the scientific exploration of Alzheimer’s Disease at four levels: clinical phenotype, cognitive neuroscience of memory, pathological and biochemical analysis of post-mortem brain tissue, and genetic analysis of patients as well as genetic mouse models of Alzheimer’s disease. This review allows me to reflect on some important ideas in James Woodward’s essay "Levels: What Are They and What Are They Good for?"