This paper presents new radiocarbon dates for two Aboriginal archaeological complexes situated on the cliff-lines of the Murray River in South Australia (SA); at Pooginook Flat and Tanamee. These dates represent the first age estimates for archaeological sites within the Upper Gorge section of the Murray River. The dates ranged from ca. 11 cal ka to the Late Holocene. The research supports previous evidence which has indicated that sites located along the Murray cliffs preserve much of the oldest evidence of Aboriginal peopling along the Murray River corridor in SA. The new dates also allow us to contribute to discussions concerning broader chronological trends in Aboriginal lifeways within the Murray-Darling Basin (MDB). Specifically, the new ages add some insight into the nature and timing of early Aboriginal occupation along the Murray River corridor in SA and further evidence that the LGM acted as a significant inhibitive factor for intensive occupation of this riverscape. The conservation of these significant and informative cliff-top sites remains precarious, however, and there is an imperative to continue to record and sample the extant sites.