This article provides a corpus-driven overview of the ‘epistemic space’ surrounding the use of two lockwords of Early and Late Modern English writings on midwifery and childbirth, child and uterus. Rather than searching for epistemic stance markers themselves, this study employs the ‘bottom-up’ approach by examining the propositions containing these lockwords, and then seeing what particular epistemic meanings are signalled by the surrounding discourse context. Both treatises and periodicals representative of medical writing from the sixteenth through the eighteenth centuries are examined, thus allowing any diachronic trends characteristic of a period that witnessed much change in midwifery practices, and medicine more broadly, to be uncovered. Data are drawn from the Early Modern English Medical Texts (EMEMT) and Late Modern English Medical Texts (LMEMT) corpora.