The purpose of this study was to examine the extent to which the Spanish POMS assesses the same factors as the original form of the questionnaire. We started from a version with 63 items, representing seven conceptual dimensions. This version was administered to a sample of 364 adult athletes. In the whole sample, exploratory factor analytic findings suggested a more parsimonious measurement model, with 44 items and 6 first-order factors. Then the data from said sample were randomly divided into two sets, each containing about 50% of the subjects. The fit of the first sample set (n = 166) to the proposed model was adequate. Four of the main goodness-of-fit indices exhibited the following values: CFI = .95, NNFI = .95, SRMR = .083, and RMSEA = .064. We tested the same model in the second data set (n = 198), in which the fit was also acceptable, with values of .95, .94, .088, and .066 for CFI, NNFI, SRMR, and RMSEA, respectively. In addition, we used multi-group confirmatory factor analysis to provide evidence on the invariance of the model.