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in-vitro activation of dormant follicles

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Chapter 14 - Is It Likely That Reproductive Aging Could Be Delayed or Reversed Using Advanced Technologies in the Future?
from Section 9 - New Technologies
- By Paula Amato, Dimitrios S. Nikolaou
Edited by Dimitrios S. Nikolaou, David B. Seifer
Book:

Optimizing the Management of Fertility in Women over 40

Published online:

15 September 2022

Print publication:

06 October 2022, pp 163-172
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Summary

This chapter explores new technologies for overcoming the problem of deteriorating oocyte-quality with age. It includes brief discussions of the following: mitochondrial replacement therapy, cytoplasmic transfer, autologous germline mitochondrial energy transfer (AUGMENT), maternal spindle transfer (MTS), in vitro activation of dormant follicles, autologous activated platelet-rich plasma injections (PRP), in vitro gametogenesis, induced pluripotent stem cells (iPSCs), aneuploidy correction through gene-editing and artificial ovaries. Clinicians should exercise extreme caution in managing patient expectations regarding these novel technologies. While clinical application of stem cell technology for maternal age-related infertility does seem likely at some point in the future, the timeline remains uncertain.