Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-cd9895bd7-p9bg8 Total loading time: 0 Render date: 2024-12-26T04:20:20.050Z Has data issue: false hasContentIssue false

Chapter 14 - Is It Likely That Reproductive Aging Could Be Delayed or Reversed Using Advanced Technologies in the Future?

from Section 9 - New Technologies

Published online by Cambridge University Press:  15 September 2022

By
Paula Amato  and
Dimitrios S. Nikolaou
Edited by
Dimitrios S. Nikolaou  and
David B. Seifer
Dimitrios S. Nikolaou
Affiliation:
Chelsea and Westminster Hospital, London
David B. Seifer
Affiliation:
Yale Reproductive Medicine, New Haven, CT
Get access

Summary

This chapter explores new technologies for overcoming the problem of deteriorating oocyte-quality with age. It includes brief discussions of the following: mitochondrial replacement therapy, cytoplasmic transfer, autologous germline mitochondrial energy transfer (AUGMENT), maternal spindle transfer (MTS), in vitro activation of dormant follicles, autologous activated platelet-rich plasma injections (PRP), in vitro gametogenesis, induced pluripotent stem cells (iPSCs), aneuploidy correction through gene-editing and artificial ovaries. Clinicians should exercise extreme caution in managing patient expectations regarding these novel technologies. While clinical application of stem cell technology for maternal age-related infertility does seem likely at some point in the future, the timeline remains uncertain.

Keywords

Mitochondrial replacement therapycytoplasmic transferAUGMENTmaternal spindle transfer (MTS)in-vitro activation of dormant folliclesautologous activated platelet-rich plasma injections (PRP)in-vitro gametogenesisinduced pluripotent stem cells (iPSCs)
Type
Chapter
Information
Optimizing the Management of Fertility in Women over 40 , pp. 163 - 172
Publisher: Cambridge University Press
Print publication year: 2022

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Faddy, MJ, Gosden, RG, Gougeon, A, Richardson, SJ, Nelson, JF. Accelerated disappearance of ovarian follicles in mid-life: implications for forecasting menopause. Human Reproduction. 1992;7(10):1342–6.Google Scholar
Santoro, N. The menopause transition: an update. Human Reproduction Update. 2002;8(2):155–60.CrossRefGoogle ScholarPubMed
Nikolaou, D. Early ovarian ageing: a hypothesis: Detection and clinical relevance. Human Reproduction. 2003;18(6):1137–9.Google Scholar
Office of National Statistics. Home – Office for National Statistics [Internet]. Ons.gov.uk. 2020. Available from: www.ons.gov.uk/Google Scholar
Ní Bhrolcháin, M, Beaujouan, É. Fertility postponement is largely due to rising educational enrolment. Population Studies. 2012;66(3):311–27.CrossRefGoogle ScholarPubMed
Welcome to the HFEA | Human Fertilisation and Embryology Authority [Internet]. hfea.gov.uk. [cited 2021 Jun 29]. Available from: http://hfea.gov.ukGoogle Scholar
Gleicher, N, Kushnir, VA, Albertini, DF, Barad, DH. Improvements in IVF in women of advanced age. The Journal of Endocrinology. 2016;230(1):F1-6.CrossRefGoogle ScholarPubMed
Reznichenko, A, Huyser, C, Pepper, M. Mitochondrial transfer: Implications for assisted reproductive technologies. Applied & Translational Genomics. 2016;11:40–7.Google Scholar
Sfakianoudis, K, Rapani, A, Grigoriadis, S, Retsina, D, Maziotis, E, Tsioulou, P, et al. Novel approaches in addressing ovarian insufficiency in 2019: are we there yet? Cell Transplantation. 2020;29:096368972092615.CrossRefGoogle ScholarPubMed
Cohen, J. Ooplasmic transfer in mature human oocytes. Molecular Human Reproduction. 1998;4(3):269–80.Google Scholar
Fakih, MH. The AUGMENTSM treatment: physician reported outcomes of the initial global patient experience. Journal of Fertilization: In Vitro – IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biology. 2015;03(03).Google Scholar
Tachibana, M, Kuno, T, Yaegashi, N. Mitochondrial replacement therapy and assisted reproductive technology: A paradigm shift toward treatment of genetic diseases in gametes or in early embryos. Reproductive Medicine and Biology. 2018;17(4):421–33.Google Scholar
Reznichenko, A, Huyser, C, Pepper, MS. Mitochondrial transfer: Ethical, legal and social implications in assisted reproduction. South African Journal of Bioethics and Law. 2015;8(2):32.CrossRefGoogle Scholar
Ernst, EH, Grøndahl, ML, Grund, S, Hardy, K, Heuck, A, Sunde, L, et al. Dormancy and activation of human oocytes from primordial and primary follicles: molecular clues to oocyte regulation. Human Reproduction. 2017;32(8):1684–700.Google Scholar
Hsueh, AJW, Kawamura, K. Hippo signaling disruption and ovarian follicle activation in infertile patients. Fertility and Sterility. 2020;114(3):458–64.Google Scholar
Tilly, JL, Telfer, EE. Purification of germline stem cells from adult mammalian ovaries: a step closer towards control of the female biological clock? Molecular Human Reproduction. 2009;15(7):393–8.Google Scholar
Sfakianoudis, K, Simopoulou, M, Grigoriadis, S, Pantou, A, Tsioulou, P, Maziotis, E, et al. Reactivating ovarian function through autologous platelet-rich plasma intraovarian infusion: pilot data on premature ovarian insufficiency, perimenopausal, menopausal, and poor responder women. Journal of Clinical Medicine. 2020;9(6).Google Scholar
Anitua, E, Prado, R, Padilla, S, Orive, G. Platelet-rich plasma therapy: another appealing technology for regenerative medicine? Regenerative Medicine. 2016;11(4):355–7.Google Scholar
Panda, SR, Sachan, S, Hota, S. A systematic review evaluating the efficacy of intra-ovarian infusion of autologous platelet-rich plasma in patients with poor ovarian reserve or ovarian insufficiency. Cureus. 2020;12(12):e12037.Google ScholarPubMed
Fazeli, Z, Abedindo, A, Omrani, MD, Ghaderian, SMH. Mesenchymal stem cells (MSCs) therapy for recovery of fertility: a systematic review. Stem Cell Reviews and Reports. 2017;14(1):1–12.Google Scholar
Thomson, JA. Embryonic stem cell lines derived from human blastocysts. Science. 1998;282(5391):1145–7.CrossRefGoogle ScholarPubMed
Kimble, J, Page, DC. The mysteries of sexual identity: the germ cell’s perspective. science. 2007;316(5823):400–1.Google Scholar
Nagy, ZP, Chang, C-C. Current advances in artificial gametes. Reproductive BioMedicine Online. 2005;11(3):332–9.Google Scholar
Takahashi, K, Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126(4):663–76.Google Scholar
Hayashi, K, Ogushi, S, Kurimoto, K, Shimamoto, S, Ohta, H, Saitou, M. Offspring from oocytes derived from in vitro primordial germ cell-like cells in mice. Science. 2012 Oct 4;338(6109):971–5.Google Scholar
Prigione, A, Lichtner, B, Kuhl, H, Struys, EA, Wamelink, M, Lehrach, H, et al. Human iPSCs harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining hESC-like metabolic reprogramming. Stem Cells. 2011;29(9):1338–1248.Google Scholar
Hockemeyer, D, Jaenisch, R. Induced pluripotent stem cells meet genome editing. Cell Stem Cell. 2016;18(5):573–86.Google Scholar
De Masi, C, Spitalieri, P, Murdocca, M, Novelli, G, Sangiuolo, F. Application of CRISPR/Cas9 to human-induced pluripotent stem cells: from gene editing to drug discovery. Human Genomics. 2020 Jun 26;14(1).Google Scholar
Cho, E, Kim, YY, Noh, K, Ku, S-Y. A new possibility in fertility preservation: The artificial ovary. Journal of Tissue Engineering and Regenerative Medicine. 2019;13(8):1294–315.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×