This chapter discusses how effective entrepreneurial education can help in developing students’ skills to enable them to become successful entrepreneurs. It first sheds light on the main skills and abilities that any entrepreneur needs in order to establish, run and maintain a prosperous start-up with long-term success. Then it describes the journey to becoming an entrepreneur, from spotting a problem-based opportunity to building a successful and sustainable start-up. Next, it explains the entrepreneurial education process and its importance for economic growth and sustainability. Based on that, the next sections elaborate on the main success factors of any entrepreneurial educational program, and what e-leadership skills are required by the different groups of stakeholders concerned with the innovation process. The chapter lists some of the main challenges that face the creation of entrepreneurial education courses and discusses some best practices that can help tackle these challenges. Furthermore, this chapter elaborates on a case study of well-planned entrepreneurial education based on successful and mutually beneficial collaboration with industry.