Acifluorfen, chlorimuron, and thiameturon were compared in single and sequential treatments for cowpea control in soybean. Chlorimuron applied once at 8.8 g ai/ha at 14, 21, and 28 days after cowpea emergence controlled 80% or more of cowpea. Control was greater at 14 and 21 than at 28 days after emergence in one of three experiments. Cowpea control by chlorimuron was similar with single and sequential treatments. Soybean injury was lower, and soybean seed yields generally were higher with chlorimuron than with thiameturon or acifluorfen. Thiameturon and acifluorfen controlled less than 60% of cowpea. Three weedy cowpea cultivars responded the same to chlorimuron, but cowpea recovery was substantial in 1 of 3 yr.