Recent reexamination of pottery, copper objects, and glass trade beads using modern analytic methods has amended the occupational history of the Cloudman site (20CH6), once interpreted as an early “Contact” period site in Michigan. The original chronology of the site, located on northern Michigan's Drummond Island in Lake Huron, was based on an apparent association of Iroquoian pottery with European-made trade goods relatively dated to circa AD 1630. Current advances in archaeological dating methods have revealed new insights into the poorly understood settlement patterns and social interactions of various Upper Great Lakes groups between AD 1300 and 1700. Accelerator mass spectrometry dating of carbonized food residue collected from late Late Woodland and Ontario Iroquoian pottery vessels suggests some contemporaneous use of both styles and the culmination of occupation by pottery-making groups by AD 1500. Elemental analysis of glass beads indicates that the recovered trade items were likely manufactured post–AD 1650. Likewise, compositional analysis of copper-base metal artifacts clarifies how such objects were made and used over time at the site. The results demonstrate how the application of modern analytic methods to curated collections can lead to significant reinterpretation, ultimately enhancing understandings of regional chronologies, social relationships, and population movements.