Continuous corn was grown for 5 consecutive yr using conservation tillage methods in the Maryland Piedmont. Herbicide treatments were applied annually at common usage rates and were compared for their effects on weed cover, species stability, and grain production. Weed flora dominance shifted from giant foxtail the first year to smooth pigweed the following year. Smooth pigweed then dominated the flora for the duration of the study. Horsenettle was ubiquitous in all treatments but never became competitive. Canada thistle occurred in measurable densities in all plots that had not received atrazine applied preemergence. Grain yields were correlated negatively with densities of smooth pigweed in 1983 (r = −0.58, P = 0.01), and Canada thistle in 1983 and 1984 (r = −0.63 and −0.62, respectively; P = 0.05). Grain yields were correlated positively with midseason precipitation (r = 0.85, P = 0.01).