In precise relative positioning applications, an effective approach to improve the interoperability of GNSS systems is the tightly combining or inter-system double-differencing of observations from the common frequencies that are shared by different constellations. As the BeiDou satellites are currently transmitting a B2 signal at 1207.14 MHz that is identical to the Galileo E5b signal, the inter-system double-differenced observations can also be created between observations from both systems at that particular frequency. In this paper, we will focus on the instantaneous ambiguity resolution performance analysis of tightly combining BeiDou B2 and Galileo E5b observations. The size and stability of phase and code Differential Inter-System Biases (DISBs) between BeiDou B2 and Galileo E5b signals are first investigated, in which the new BeiDou and Galileo satellites launched recently will also be included. Then, first results of the Tightly Combined Model (TCM) with a priori corrected DISBs (TCM_C) are evaluated in comparison to the Loosely Combined Model (LCM) and tightly combined model with unknown DISBs (TCM_F) in an instantaneous approach. It is demonstrated that the instantaneous integer ambiguity resolution performance can be improved using the TCM_C with respect to LCM and TCM_F.