BASF Corp. has developed p-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor–resistant cotton and soybean that will allow growers to use isoxaflutole in future weed management programs. In 2019 and 2020, a multi-state non-crop research project was conducted to examine weed control following isoxaflutole applied preemergence alone and with several tank-mix partners at high and low labeled rates. At 28 d after treatment (DAT), Palmer amaranth was controlled ≥95% at six of seven locations with isoxaflutole plus the high rate of diuron or fluridone. These same combinations provided the greatest control 42 DAT at four of seven locations. Where large crabgrass was present, isoxaflutole plus the high rate of diuron, fluridone, pendimethalin, or S-metolachlor or isoxaflutole plus the low rate of fluometuron controlled large crabgrass ≥95% in two of three locations 28 DAT. In two of three locations, isoxaflutole plus the high rate of pendimethalin or S-metolachlor improved large crabgrass control 42 DAT when compared to isoxaflutole alone. At 21 DAT, morningglory was controlled ≥95% at all locations with isoxaflutole plus the high rate of diuron and at three of four locations with isoxaflutole plus the high rate of fluometuron. At 42 DAT at all locations, isoxaflutole plus diuron or fluridone and isoxaflutole plus the high rate of fluometuron improved morningglory control compared to isoxaflutole alone. These results suggest that isoxaflutole applied preemergence alone or in tank mixture is efficacious on a number of cross-spectrum annual weeds in cotton, and extended weed control may be achieved when isoxaflutole is tank-mixed with several soil-residual herbicides.

Quizalofop controlled 2- to 3-leaf and 5- to 6-leaf red rice better than fluazifop-P, haloxyfop, or sethoxydim applied alone. Red rice control increased when acifluorfen was tank mixed with haloxyfop, fluazifop-P, or sethoxydim. Antagonism was most severe when imazaquin was tank mixed with any of the grass herbicides. The efficacy of sethoxydim, fluazifop-P, and haloxyfop was reduced when applied with chlorimuron or bentazon. In greenhouse experiments, all of the grass herbicides, except for fenoxaprop, reduced fresh weight of red rice 71% or more. Based on fresh weight reduction, acifluorfen, fomesafen, and lactofen only reduced the activity of fluazifop-P, while imazaquin decreased the activity of all grass herbicides.

Antagonism was evaluated among four grass and seven broadleaf herbicides applied postemergence for seedling and rhizome johnsongrass control in soybeans. Imazaquin and chlorimuron were most antagonistic to grass herbicides. Haloxyfop and quizalofop were least affected by the addition of broadleaf herbicides. Johnsongrass control was reduced 11 to 46% when grass herbicides were applied with broadleaf herbicides and were evaluated 3 and 12 weeks after treatment (WAT).

Field studies were conducted to evaluate corn vigor reduction, weed control, corn yield, and economic returns in a no-till system with various herbicide strategies using full and reduced rates of acetochlor and atrazine with glyphosate, glufosinate, or imazethapyr + imazapyr in their respective type of herbicide-resistant, no-tillage corn. Crop vigor reduction due to herbicide injury was 10% or less with all treatments. A burndown plus a full label rate of a residual herbicide applied early preplant (EPP) generally provided less than 80% control of giant foxtail, common waterhemp, and common cocklebur but usually greater than 85% control of common ragweed and common lambsquarters. Two-pass strategies generally provided greater than 85% control of all species evaluated. Early postemergence, mid-postemergence (MPOST), and late postemergence strategies generally provided inconsistent and poor overall weed control. EPP–MPOST strategies generally provided lower weed control than strategies using acetochlor or atrazine EPP followed by a postemergence application. Corn yield and net economic returns followed a similar trend as weed control, with strategies that provided greater than 80% weed control showing minimal crop vigor reduction and high grain yields. Two-pass strategies with residual herbicides generally provided the highest yields, economic returns, and low coefficients of variation (CV) of net income. Although EPP strategies provided similar economic returns as some of the two-pass strategies, they had higher CVs, implying greater risk to economic return.