This research investigates the MIMO antenna by using the Theory of Characteristics Mode (TCM) where 10 modes are subjected in designing. Also, 5 modes are the significant mode and 2 modes correspond to non-significant which defines the operating bandwidth and notched bands. The proposed 2 × 2 MIMO antenna configuration is designed for wideband applications with a size of 0.44 × 0.68 mm2. The two isolated 12-sided polygons radiating patches placed adjacent to each other share a common ground which is printed on an FR4 substrate. The measured impedance bandwidth covers bandwidth 3.11–11.98 GHz with two bands rejecting capability: Wireless Local Area Network (WLAN) and Downlink-Uplink Satellite (DUS) system. These two interfering bands are mitigated by etching a C-type slot on the radiating patch and an inverted U-type slot in the microstrip feed. The simulated and measured results are also compared in the far-field region (Normalized Radiation Efficiency (NRE), Peak Gain (PG), and 2-D/3-D radiation pattern). Proposed MIMO antenna also offers good diversity performance with ECC2×2 < 0.00001, DG2×2 > 9.999 dB, TARC2×2 < −15.0 dB, CCL2×2 < 0.001 b/s/Hz and MEG2×2 ≅ −3.0 dB.

The objective of the present study was to find the optimum dose of flaxseed that would decrease PG and alter oestrogen pathway endpoints implicated in ovarian cancer. In the study, four groups of fifty 1·5-year-old chickens were fed different amounts of flaxseed (0, 5, 10 or 15 % of their total diet) for 4 months and were then killed to collect blood and tissues. Levels of flaxseed lignan metabolites, Enterolactone (EL) and Enterodiol (ED) were measured in the serum, liver and ovaries by liquid chromatography–MS/MS, and n-3 and n-6 fatty acid (FA) levels were measured by GC. The effects of the varied flaxseed doses were assessed by measuring levels of PGE2 and oestrogen metabolites (16-hydroxyestrone (16-OHE1) and 2-hydroxyestrone (2-OHE1)) as well as by analysing the expression of the oestradiol metabolising enzymes CYP3A4 (cytochrome p450, family 3, subfamily A, polypeptide 4), CYP1B1 (cytochrome p450, family 1, subfamily B, polypeptide 1) and CYP1A1 (cytochrome p450, family 1, subfamily A, polypeptide 1) and that of oestrogen receptor α (ERα) in the ovaries. The ratio of n-3:n-FA increased with an increase in flaxseed supplementation and corresponded to a dose-dependent decrease in cyclo-oxygenase-2 protein and PGE2 levels. EL and ED increased in the serum, liver and ovaries with increased concentrations of flaxseed. Flaxseed decreased the expression of ERα in the ovaries. The ratio of 2-OHE1:16-OHE1 in the serum increased significantly in the 15 % flaxseed diet, and there was a corresponding increase in CYP1A1 in the liver and decrease in CYP3A4 in the ovaries. CYP1B1 mRNA also decreased with flaxseed diet in the ovaries. The 15 % flaxseed-supplemented diet significantly decreased inflammatory PGE2, ERα, CYP3A4, CYP1B1 and 16-OHE1, but it increased CYP1A1 and 2-OHE1, which thus reduced the inflammatory and pro-carcinogenic micro-environment of the ovaries.