The international community has been struggling to reach agreement on the non-proliferation and elimination of nuclear weapons since they were first used in 1945. Encouragingly, recent global debate has, for the first time, focused on the devastating humanitarian consequences that the use of nuclear weapons will have not only for nuclear weapons States but for all humanity. The fact that the risks and overwhelming humanitarian consequences of a nuclear event are so high, combined with the inability of the global community to adequately respond to the needs of victims, has compelled policy-makers to consider new ways to work towards the prohibition of the use of nuclear weapons under international law. This article examines how the “humanitarian initiative” has reframed the nuclear weapons debate away from the traditional realm of State security, deterrence and military utility, and towards the grim reality of the humanitarian impacts that would confront humankind if nuclear weapons were ever used again.