This study builds upon our prior work to further explore and unravel the effects of saturated thermal conduction within a viscous resistive MHD framework on the intricate transport mechanisms of angular momentum and energy in disc-jet systems. We conducted a series of 2.5-dimensional non-relativistic time-dependent numerical simulations using the PLUTO code. Employing a saturation parameter spanning [0.002-0.01], our results are consistent with previous investigations that omitted consideration of thermal conduction, affirming the established understanding that kinetic torque plays a predominant role in governing the total accretion angular momentum, surpassing the magnetic contribution within the disc. At the initial time steps of our calculations, we find that thermal conduction enhances this kinetic contribution, while concurrently diminishing the effect of magnetic contribution. In contrast to the prevailing influence of kinetic torque within the disc, we also assert the magnetic torque as the primary contributor to the total ejection angular momentum. We further unveil that doubling the saturation parameter leads to bolstering of approximately $23.7\%$ in the integral dominance of magnetic torque compared to kinetic torque within the jet. Our findings reveal that doubling the effect of thermal conduction improves the integral total accretion power by approximately 2%, thereby slightly amplifying the energy content within the system and increasing overall energy output. We underscore that as the local energy dissipation within the disc intensifies, the significance of the enthalpy accretion flux increases at the expense of the jet power. We reveal that increasing the saturation parameter mitigates enthalpy accumulation within the disc, and further restricts the jet’s energy extraction from the disc. This limitation is determined in our analysis through the decrease in the integral ratio between the bipolar jet and liberated power of approximately $13.8\%$, for twice the strength of the saturation parameter. We identify the Poynting flux as the primary contributor to total jet power, with thermal conduction exerting minimal influence on magnetic contributions. Additionally, we emphasise the integration of jet enthalpy as another significant factor in determining overall jet power, highlighting a distinct correlation between the rise in saturation parameter and heightened enthalpy contribution. Moreover, we observe the promotion of Poynting flux over kinetic flux at advanced time steps of our simulations, a trend supported by the presence of thermal conduction, which demonstrates an integral increase of approximately $11.2\%$ when considering a doubling of the saturation parameter.

Our aim was to disentangle the effects of different heat sources and the non-thermal properties of the substrate in the microhabitat choices of two lizard species living in savanna habitats of central-western Brazil: the teiid Ameivula aff. ocellifera (N = 43) and the tropidurid Tropidurus oreadicus (N = 23). To this end, a mixed structural resource selection function (mixed-SRSF) approach was used, modelling the probability of finding a lizard on a certain microhabitat based on environmental variables of used and simultaneously available places. First, we controlled for the effects of solar radiation, convection and the physical thermal properties of the substrate on substrate temperature. Then we assessed the effects of solar radiation, convection, conduction and the non-thermal properties of the substrate in the probability of use of a certain microhabitat. Results confirmed that substrate temperature was mediated by: air convection > solar radiation > physical thermal properties of the substrates. Moreover, the mixed-SRSF revealed that direct solar radiation and the non-thermal properties of the substrates were the only drivers of microhabitat selection for both species, with approximately the same strength. Our novel approach allowed splitting of the effect of different mechanisms in the microhabitat selection of lizards, which makes it a powerful tool for assessing the conformation of the interactions between different environmental variables mediating animal behaviour.

Cardiac conduction disease affects patients with Kearns–Sayre syndrome. We report a young asymptomatic patient with Kearns–Sayre syndrome with abnormal conduction on electrocardiogram and Holter monitor, although not advanced atrioventricular block. She underwent prophylactic pacemaker placement, and rapidly developed complete atrioventricular block, which resulted in 100% ventricular pacing. It may be reasonable to consider prophylactic pacemaker implantation in patients with Kearns–Sayre syndrome with evidence of cardiac conduction disease even without overt atrioventricular block given its unpredictable progression to complete atrioventricular block.

Radio-mode feedback from relativistic jets is one of the prominent heating mechanisms in clusters of galaxies. We present a long-term evolution of high-resolution MHD simulation of jets interacting with an environment modeled to represent the Perseus cluster. We investigate the thermodynamics of the ICM due to the gas motion triggered by the action of the jets and show that low-entropy gas is lifted efficiently in the wake of the inflating radio lobe. We look into the uplift mechanism and estimate the energy budget and the rate of thermal conduction. The redistribution of entropy suggests that heat conduction can play a more significant role in the thermal evolution of the cluster core in the presence of jets, which act effectively as a heat pump, thus heating the ICM more efficiently than jets would by themselves in an isentropic cluster.

We have constrained the value for thermal diffusivity of near-surface snow and firn at Summit Station, Greenland, using a Fourier-type analysis applied to hourly temperature measurements collected from eight thermistors in a closed-off, air-filled borehole between May 2004 and July 2008. An implicit, finite-difference method suggests that a bulk diffusivity of ∼25 ± 3m2 a−1 is the most reasonable for representing macroscale heat transport in the top 30 m of firn and snow. This value represents an average diffusivity and, in a conduction-only model, generates temperature series whose phase shifts with depth most closely match those of the Summit borehole data (rms difference between measurements and model output is ∼6 days). This bulk value, derived numerically and corroborated analytically, is useful over large tracts of the Greenland ice sheet where density and microstructure are unknown.

While several scenarios have been proposed to explain supra-arcade downflows (SADs) observed descending through turbulent hot regions, none of them have systematically addressed the consideration of thermal conduction. The SADs are known to be voided cavities. Our model assumes that SADs are triggered by bursty localized reconnection events that produce non-linear waves generating the voided cavity. These subdense cavities are sustained in time because they are hotter than their surrounding medium. Due to the low density and large temperature values of the plasma we expect the thermal conduction to be an important process. Our main aim here is to study if it is possible to generate SADs in the framework of our model considering thermal conduction. We carry on 2D MHD simulations including anisotropic thermal conduction, and find that if the magnetic lines envelope the cavities, they can be isolated from the hot environment and be identified as SADs.

We developed a model for wind-blown bubbles with temperature and density profiles based on self-similar solutions including thermal conduction. We constructed also heat-conduction bubbles with chemical discontinuities. The X-ray emission is computed using the well-documented CHIANTI code (v6.0.1). These bubble models are used to (re)analyse the high-resolution X-ray spectrum of the hot bubble of BD+30°3639, and they appeared to be much superior to constant temperature approaches.

We found for the X-ray emission of BD+30°3639 that temperature-sensitive and abundance-sensitive line ratios computed on the basis of heat-conducting wind-blown bubbles and with abundances as found in the stellar photosphere/wind can only be reconciled with the observations if the hot bubble of BD+30°3639 is chemically stratified, i.e. if it contains also a small mass fraction (≃ 3 %) of hydrogen-rich matter immediately behind the conduction front. Neon appears to be strongly enriched, with a mass fraction of at least about 0.06.

The unmatched X-ray resolution of Chandra allows probing the gas flow near quiescent supermassive black holes (BHs). The radius of BH gravitational influence on gas, called the Bondi radius, is resolved in Sgr A* and NGC 3115. Shallow accretion flow density profiles n ∝ r−β with β=0.7–1.0 were found for Sgr A* and NGC 3115 with the help of Chandra. We construct self-consistent models with gas feeding and dynamics from near the Bondi radius to the event horizon to explain the observations. Gas is mainly supplied to the region by hot colliding stellar winds. Small-scale feedback such as conduction effectively flattens the density profile from steep β=1.5 in a Bondi flow. We further constrain density and temperature profiles using the observed radio/sub-mm radiation emitted near the event horizon. We discuss the present state of our numerical model and its qualitative features, such as the role of the galactic gravitational potential and the random motion of wind-emitting stars.

We investigate 10 M-class flares observed by the SOXS mission to study the influence of the solar flare plasma cooling on the Neupert effect. We study the temporal evolution of 1s cadence X-ray emission in 7-10 keV and 10-30 keV representing the SXR and HXR emission respectively. We model the cooling as a function of time by the ratio of time-derivative of SXR with the HXR flux. We report that the ratio is exponentially decaying in rise phase of the flare, which, however, saturates after the impulsive phase. We estimate the cooling time scale in the rise phase for the flares and found to be varying between 39 and 525 s.

Based on time-dependent radiation-hydrodynamics simulations of the evolution of Planetary Nebulae (PNe), we have carried out a systematic parameter study to address the non-trivial question of how the diffuse X-ray emission of PNe with closed central cavities is expected to depend on the evolutionary state of the nebula, the mass of the central star, and the metallicity of stellar wind and circumstellar matter. We have also investigated how the model predictions depend on the treatment of thermal conduction at the interface between the central ‘hot bubble’ and the ‘cool’ inner nebula, and compare the results with recent X-ray observations. Our study includes models whose properties resemble the extreme case of PNe with Wolf-Rayet type central stars. Indeed, such models are found to produce the highest X-ray luminosities.

As a tool helping to interpret diffuse X-ray emission of PNe, and as a supplement to our RHD simulations, we have started to construct a grid of theoretical X-ray spectra of wind-blown bubbles with temperature and density profiles according to thermal conduction theory. We investigate how the X-ray spectra depend on chemical composition (e.g. H-rich vs. H-deficient) and how temperature and abundance determinations reflect gradients of temperature and chemical composition within the bubbles. These synthetic models shall allow to quickly perform detailed parameter studies without the need for dedicated hydrodynamical simulations. We report on ideas and goals.

X-ray observations of young Planetary Nebulæ (PNe) have revealed diffuse emission in extended regions around both H-rich and H-deficient central stars. In order to also reproduce physical properties of H-deficient objects, we have, at first, extended our time-dependent radiation-hydrodynamic models with heat conduction for such conditions. Here we present some of the important physical concepts, which determine how and when a hot wind-blown bubble forms. In this study we have had to consider the, largely unknown, evolution of the CSPN, the slow (AGB) wind, the fast hot-CSPN wind, and the chemical composition. The main conclusion of our work is that heat conduction is needed to explain X-ray properties of wind-blown bubbles also in H-deficient objects.

The state of knowledge about the structure and composition of icy satellite interiors has been significantly extended by combining direct measurements from spacecraft, laboratory experiments, and theoretical modeling. Interior models of icy bodies will certainly benefit from future missions to the outer solar system, providing new and improved constraints on the surface chemistry, bulk composition and degree of internal differentiation, possible heterogeneities in radial mass distribution, the presence and extent of liquid reservoirs, and the amount of tidal heating for each target body. Here we summarize geophysical constraints on the interior structure and composition of selected Jovian and Saturnian icy satellites and investigate conditions under which potentially habitable liquid water reservoirs could be maintained. Future geophysical exploration which includes gravitational and magnetic field sounding from low-altitude orbit and close flyby, combined with altimetry data and in-situ monitoring of tidally-induced surface distortion and time-variable magnetic fields, would impose important constraints on the interiors of outer planet satellites.

In this paper, we compare a biomechanics empirical model of the heart fibrous structure to two models obtained by a non-periodic homogenization process. To this end, the two homogenized models are simplified using the small amplitude homogenization procedure of Tartar, both in conduction and in elasticity. A new small amplitude homogenization expansion formula for a mixture of anisotropic elastic materials is also derived and allows us to obtain a third simplified model.

A series solution is presented for a spherical inclusion embedded in an infinite matrix under a remotely applied uniform intensity. Particularly, the interface between the inclusion and the matrix is considered to be inhomegeneously bonded. We examine the axisymmetric case in which the interface parameter varies with the cone angle θ. Two kinds of imperfect interfaces are considered: an imperfect interface which models a thin interphase of low conductivity and an imperfect interface which models a thin interphase of high conductivity. We show that, by expanding the solutions of terms of Legendre polynomials, the field solution is governed by a linear set of algebraic equations with an infinite number of unknowns. The key step of the formulation relies on algebraic identities between coefficients of products of Legendre series. Some numerical illustrations are presented to show the correctness of the presented procedures. Further, solutions of the boundary-value problem are employed to estimate the effective conductivity tensor of a composite consisting of dispersions of spherical inclusions with equal size. The effective conductivity solely depends on one particular constant among an infinite number of unknowns.

Background and objective: Similar doses of ketamine are employed in regional and general anaesthesia. In contrast to commonly used local anaesthetic agents, accidental systemic application of local anaesthetic doses of ketamine will not result in seizure, dysrhythmia or cardiovascular depression. However, there is some doubt about the quality of regional analgesia induced by ketamine. As human sodium channels constitute an important molecular target of local anaesthetics, the study was designed to establish concentration-dependent effects of ketamine on conductance, steady-state activation and steady-state inactivation of human neuronal sodium channels. This information — that has, so far, not been published — will help to characterize further local anaesthetic properties of ketamine.

Methods: Whole-cell patch-clamp recordings were made of sodium channels natively expressed in human neuroblastoma SH-SY5Y cells.

Results: The sodium channels activated at a threshold of −60 mV and exhibited a maximal peak current at −10 mV. The voltage of half-maximal activation was −20 mV. The Na+ currents depended on the prepulse potential. The voltage of half-maximal inactivation was —80 mV. Ketamine inhibited the sodium conductance in a concentration-dependent manner (IC50 = 1140 µmol). A concentration-dependent hyperpolarizing shift of both steady-state activation and steady-state inactivation accounted for at most 5 mV.

Conclusions: The effects of ketamine on these human ion channels occur at clinical concentrations. They are consistent with the local anaesthetic action of ketamine. Whether ketamine helps to decrease the incidence of severe side-effects during regional anaesthesia needs to be addressed in further clinical studies.

Background and objective: The aim of this prospective, randomized study was to compare the preparation and discharge times, the side-effects and patient satisfaction after gynaecological outpatient procedures performed using either spinal block or total intravenous anaesthesia with propofol and remifentanil.

Methods: With Ethics Committee approval and written informed consent, 40 healthy females scheduled for hysteroscopic ablation of endometrial neoplasm were randomly allocated to receive either a spinal block with bupivacaine 0.5% hyperbaric solution 10 mg (n = 20) or total intravenous anaesthesia with propofol and remifentanil (n = 20). Preparation and discharge times, as well as occurrence of untoward events and anaesthesiarelated costs, were recorded.

Results: The median (range) preparation time was 7 (7–10) min with general anaesthesia, and 11 (7–21) min with spinal block (P = 0.00005). No differences in discharge time from the postanaesthesia care unit and incidence of hypotension or bradycardia, or both, were reported between the two groups. Hospital discharge times were 156 (101–345) min after general anaesthesia and 296 (195–720) min after spinal anaesthesia (P = 0.0005). Acceptance of the anaesthesia technique was better after general (100%) than after spinal anaesthesia (75%) (P = 0.04). No differences in total costs were reported between spinal block (€155 (€117–€224)) and propofol-remifentanil general anaesthesia (€143 (€124–€203) (P = 0.125)).

Conclusions: Accurate titration of short-acting intravenous anaesthetic drugs such as propofol and remifentanil results in shorter preparation times and earlier home discharge after outpatient gynaecological procedures compared with spinal anaesthesia with hyperbaric bupivacaine 10 mg, with better patient acceptance and no increased costs.