Downy brome is one of the leading plant pests in winter wheat and no-till spring wheat in many areas of the country. It has recently been studied in North Dakota where it is emerging as a serious crop competitor. Downy brome plants produced up to 60 tillers and more than 7,500 seeds when no control measures were used and densities were less than 2 plants m−2. Experiments focusing on herbicide-application timing identified differences in downy brome control and the grain yield of spring wheat. Regardless of fall or spring application timing, glyphosate applied PRE to wheat completely controlled downy brome in 2007. In 2008, control was not achieved with the earliest glyphosate-application timings because of late-emerging plants. When comparing fall and spring application timings of other herbicides, imazapic provided at least 79% control at each timing and location, resulting in the highest imazamox-resistant spring wheat yield. In general, herbicides performed better when applied in fall than they did when applied in spring. When herbicides were applied POST, imazamox provided the greatest downy brome control and usually caused the largest numerical reduction in downy brome biomass, seed, and stem number. If downy brome was left untreated, regression analysis predicted approximately 2,000 stems m−2 could result in total yield loss of spring wheat.