This article analyses the political impact of the 1918 influenza pandemic in Spain, a hitherto scarcely explored subject. It first discusses the evolution and impact of the pandemic, focusing on political and social responses. It then shows how these responses were related to debates about the crisis of Restoration Spain's political system. Lastly, it analyses the long-term political impact of the influenza pandemic, showing how the demands of this period can be linked to policies and discourses during the Primo de Rivera dictatorship, particularly regarding the links between the call for a ‘health dictatorship’ developed during the pandemic and the rhetorical use of medical language linked to authoritarian regenerationism between 1923 and 1930.