Madonna's book Sex (1992) is the world's largest-grossing illustrated book, selling 1.4 million copies worldwide and earning US$70 million in sales at retail. This essay is the first to use methods from the discipline of bibliography to analyze the book's production, distribution, and reception. This article extends scholarship on Madonna, including about her iconicity and visuality, from her songs and videos to her print culture. I demonstrate how Sex – both as a printed book and as an expression of national culture – is part of a dynamic American book history that constructs notions of America, including freedom of speech, thought, and religion.