All Cardiophorus species found in Canada and the United States of America east of the Rocky Mountains are keyed and all but those with the majority of their ranges west of the Rocky Mountains are revised. Eleven species are recognized, three of which are new to science (C. catskillensissp. nov., C. destinensissp. nov., and C. panamapolissp. nov.). Cardiophorus floridae Candèze and C. angustatus Blanchard are synonymized under C. convexus (Say). All 11 are described and taxonomically important characters are presented. Distribution maps are presented for each species. The following lectotypes are designated for species that were described from more than one specimen without former holotype designation: C. angustatus, C. floridae, C. erythropus Erichson, C. gagates Erichson, C. togatus Horn, C. robustus LeConte, C. convexulus LeConte, and C. amictus Melsheimer. The following neotypes were designated to replace destroyed type specimens: C. cardisce (Say) and C. convexus.