Nowotny chimney-ladder compounds RuAl2 and RuGa2 have been substituted with p- and n-type dopants to study the resistivity, Seebeck and Hall coefficients, and thermal conductivity of resulting compounds in the temperature range of 80–300 K. The resistivity and Seebeck coefficient suggest that these compounds are degenerate semiconductors. Hall measurements reveal that the carrier concentration has indeed been changed by an order of magnitude, particularly in p-type RuGa2 by substituting Cr and Mn. Compared to p-type samples, the resistivity is an order of magnitude larger for n-type samples, for a similar level of carrier concentration. Interestingly, the hole mobility is two to three orders of magnitude larger, reaching the highest value of ∼750 cm2/V·s. The electron mobility is temperature independent and is typically in the range of ∼1–4 cm2/V·s. Thermal conductivity shows characteristics of mixed scattering with impurity scattering contributing appreciably in heavily substituted compositions.