Ten commercial soybean [Glycine max (L.) Merr.] cultivars were evaluated for reaction to over-the-top applications of two rates of 3′,4′-dichloropropionanilide (propanil) at the growth stage when three nodes on the main stem had completely unrolled leaves. Propanil, a herbicide commonly applied to rice [Oryza sativa L.] for control of grass weeds, was applied at 0.56 and 3.36 kg/ha; the higher rate is commonly used for control of weeds in rice. ‘Davis’, ‘Hood’, and ‘York’ soybean cultivars were damaged more by propanil than ‘Hill’, ‘Lee’, ‘Lee 68’, ‘Pickett’, ‘Semmes’, ‘Bragg’, or ‘Dare’ when damage was measured by reductions in seed yield and stand and by leaf injury.