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Accepted manuscript

Dietary fat quality indices and risk of pre-diabetes and type 2 diabetes mellitus: Tehran Lipid and Glucose Study

Published online by Cambridge University Press:  09 December 2024

Zahra Gaeini ,
Sevda Alvirdizadeh ,
Somayeh Hosseinpour-Niazi ,
Parvin Mirmiran  and
Fereidoun Azizi
Zahra Gaeini
Affiliation:
Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Sevda Alvirdizadeh
Affiliation:
Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Somayeh Hosseinpour-Niazi
Affiliation:
Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Parvin Mirmiran*
Affiliation:
Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Fereidoun Azizi
Affiliation:
Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
*
Correspondence to Parvin Mirmiran, P.O. Box: 19395-4763, Phone: +98 (21) 224 32 500, Fax: +98 (21) 224 16 264, 224 02 463, Email address: [email protected], Address: No. 24, Shahid-Erabi St., Yeman St., Velenjak, Tehran, Iran
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Abstract

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Objective:

To assess associations between dietary fat quality indices (FQI) and risk of pre-diabetes and type 2 diabetes mellitus (T2DM) among Iranian adults.

Design:

Daily intakes of fatty acids were estimated using a validated food frequency questionnaire with 168 food item. Adjusted hazard Ratios (HRs) and 95% confidence intervals (CIs) of pre-diabetes and T2DM were calculated in tertile categories of dietary FQI including atherogenic index (AI), thrombogenic index (TI), health promoting index (HPI), ratio of poly-unsaturated fatty acids to saturated fatty acids (PUFA/SFA) and ratio of hypo and hypercholesterolemia (h/H).

Setting:

Tehran Lipid and Glucose Study.

Participants:

Iranian men and women.

Results:

Mean (±SD) age of the 2042 pre-diabetes-free participants in pre-diabetes analysis was 38.84 (12.97), and 55.2% were women. In T2DM analysis, mean (±SD) age of the 2295 T2DM-free participants was 40.06 (13.42), and 54.6% of them were women. In the crude model, PUFA/SFA ratio was positively associated with T2DM incidence (HR=1.43, 95% CI: 1.04-1.98). However, after adjustment for confounding variables, there were no significant associations between dietary FQI and risk of pre-diabetes and T2DM.

Conclusions:

We found no significant association between FQI and risk of pre-diabetes and T2DM. Further prospective and clinical trial studies are needed to clarify the issue.

Keywords

fat quality indicespre-diabetestype 2 diabetes mellitus
Type
Research Paper
Information
Public Health Nutrition , Accepted manuscript , pp. 1 - 25
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
Copyright
© The Authors 2024