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Seasonal influences on the functional expression of the endogenous L-type Ca2+ channels in Pleurodeles oocytes: role of cAMP?

Published online by Cambridge University Press:  05 April 2001

Halima Ouadid-Ahidouch  and
Fabien Van Coppenolle
Halima Ouadid-Ahidouch
Affiliation:
Centre de Biologie Cellulaire, Laboratoire de Physiologie Cellulaire, SN3, USTL, Villeneuve d'Ascq 59655, France
Fabien Van Coppenolle
Affiliation:
Centre de Biologie Cellulaire, Laboratoire de Physiologie Cellulaire, SN3, USTL, Villeneuve d'Ascq 59655, France
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Abstract

We have investigated the seasonal regulation of the Ba current (IBa) through the L-type Ca2+ channels in Pleurodeles oocytes and its relation with the intracellular cAMP level. IBa-density remained relatively constant from January to February, increased from March to April (with a maximum increase in March) and decreased from May to July. While the permeable cAMP analogue 8Br-cAMP reduced IBa during the breeding season, it was without effect during the resting season. However, IBa recorded during the two seasons was increased by a dihydropyridine agonist Bay K 8644 and blocked by cadmium. The main conclusion is that the seasonal reduction in the L-type Ca2+ current amplitude may be correlated with a high intracellular cAMP level and may account for the inability of oocytes to mature during the resting season.

Keywords

cAMPL-type Ca2+ channelMaturationPleurodeles oocytes
Type
Research Article
Information
Zygote , Volume 6 , Issue 2 , May 1998 , pp. 97 - 101
Copyright
1998 Cambridge University Press

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