Hostname: page-component-7479d7b7d-q6k6v Total loading time: 0 Render date: 2024-07-08T13:49:51.669Z Has data issue: false hasContentIssue false
  • English
  • Français

The contributions of source regions to organ doses from incorporated radioactive iodine

Published online by Cambridge University Press:  01 August 2014

E. Hoseinian-Azghadi ,
L. Rafat-Motavalli  and
H. Miri-Hakimabad
Get access

Abstract

The separate contributions of all source regions to organ doses from 131I and 123I administered to the body were calculated using voxelized reference phantoms. The photon and electron components of organ doses were also evaluated for each source region. The MCNPX Monte Carlo particle transport code was utilized for dose calculations. All organs and tissues of male and female phantoms were taken into account as source regions with their corresponding cumulated activities. The results showed that cumulated activities assigned to source regions and inter-organ distances were two factors that strongly affected the contribution of each source to the organ dose. The major contribution of the dose to the main source regions arose from self-irradiation of electrons, while for nearby organs it was due to photons emitted by the main source organs. In addition, self-irradiation plays an important role in the dose delivered to most target organs for lower thyroid uptakes.

Keywords

Internal dosevoxel phantomsthyroid agents
Type
Article
Information
Radioprotection , Volume 49 , Issue 4 , October 2014 , pp. 249 - 256
Copyright
© EDP Sciences, 2014

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bolch, W.E., Eckerman, K.F., Sgouros, G., Thomas, S.R. (2009) MIRD pamphlet no. 21: a generalized schema for radiopharmaceutical dosimetry – standardization of nomenclature, J. Nucl. Med. 50, 477-484. Google ScholarPubMed
ENSDF Decay Data in the MIRD (Medical Internal Radiation Dose) Format. National Nuclear Data Center: Brookhaven National Laboratory, Upton, N.Y., USA. http://www.orau.org/ptp/PTP%20Library/library/DOE/bnl/nuclidedata/MIRI131.htm (1 January 2014, date last accessed).
Hadid, L., Gardumi, A., Desbrée, A. (2013) Evaluation of absorbed and effective doses to patients from radiopharmaceuticals using the ICRP 110 reference computational phantoms and ICRP 103 formulation, Radiat. Prot. Dosim. 156 (2), 141-159. Google ScholarPubMed
Hoseinian-Azghadi, E., Rafat-Motavalli, L., Miri-Hakimabad, H. (2013) Internal dosimetry estimates using voxelized reference phantoms for thyroid agents, J. Radiat. Res. 55 (3), 407-422. Google ScholarPubMed
ICRP Publication 30 (1982) Limits for Intakes of Radionuclides by Workers, Ann. ICRP 8 (4).
ICRP Publication 38 (1983) Radionuclide Transformations – Energy and Intensity of Emissions, Ann. ICRP 11-13.
ICRP Publication 53 (1988) Radiation dose to patients from radiopharmaceuticals, Ann. ICRP 18 (1-4).
ICRP Publication 60 (1991) Recommendations of the International Commission on Radiological Protection, Ann. ICRP 21 (1-3).
ICRP Publication 80 (1998) Radiation Dose to Patients from Radiopharmaceuticals (Addendum to ICRP Publication 53), Ann. ICRP 28 (3).
ICRP Publication 89 (2002) Basic anatomical and physiological data for use in radiological protection: reference values, Ann. ICRP 32 (3-4).
ICRP Publication 100 (2006) Human alimentary tract model for radiological Protection, Ann. ICRP 36 (1-2).
ICRP Publication 106 (2008) Radiation Dose to Patients from Radiopharmaceuticals – Addendum 3 to ICRP Publication 53, Ann. ICRP 38 (1-2).
ICRP Publication 107 (2008) Nuclear Decay Data for Dosimetric Calculations, Ann. ICRP 38 (3).
ICRP Publication 110 (2009) Adult Reference Computational Phantoms, Ann. ICRP 39 (2).
Lamart, S., Bouville, A., Simon, S.L., Eckerman, K.F., Melo, D., Lee, C. (2011) Comparison of internal dosimetry factors for three classes of adult computational phantoms with emphasis on I-131 in the thyroid, Phys. Med. Biol. 56 (22), 7317-7335. Google Scholar
Phipps, A.W., Fell, T.P., Harrison, J.D., Paquet, F., Leggett, R.W. (2007) Dose coefficients calculated using the new ICRP model for the human alimentary tract, Radiat. Prot. Dosim. 127 (1-4), 79-85. Google Scholar
Smith, T., Petoussi-Henss, N., Zankl, M. (2000) Comparison of internal radiation doses estimated by MIRD and voxel techniques for a ‘family’ of phantoms, Eur. J. Nucl. Med. 27 (9), 1387-1398. Google ScholarPubMed
Wang, J.N., Lee, K.W., Jiang, S.H. (2014) Effective dose evaluation for BNCT brain tumor treatment based on voxel phantoms, Appl. Radiat. Isotopes 88, 55-58. Google ScholarPubMed
Zankl, M., Petoussi-Henss, N., Janzen, T., Uusijärvi, H., Schlattl, H., Li, W.B., Giussani, A., Hoeschen, C. (2010) New calculations for internal dosimetry of beta-emitting radiopharmaceuticals, Radiat. Prot. Dosim. 139 (1-3), 245-249. Google ScholarPubMed
Zankl M., Schlattl H., Petoussi-Henss N., Hoeschen C. (2011) Voxel phantoms for internal dosimetry. In: Radiation Physics for Nuclear Medicine (M.C. Cantone, C. Hoeschen, Eds.), pp. 257-279. Springer, Berlin.