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Volume 48 - July 2018

Contents

Page 16 of 17

Correspondence

Front Cover (OFC, IFC) and matter

  • PSM volume 48 issue 1 Cover and Front matter

  • Published online by Cambridge University Press:
    12 December 2017, pp. f1-f2
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  • PSM volume 48 issue 14 Cover and Front matter

  • Published online by Cambridge University Press:
    07 September 2018, pp. f1-f2
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  • PSM volume 48 issue 4 Cover and Front matter

  • Published online by Cambridge University Press:
    08 February 2018, pp. f1-f2
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Corrigendum

Back Cover (IBC, OBC) and matter

  • PSM volume 48 issue 13 Cover and Back matter

  • Published online by Cambridge University Press:
    05 September 2018, pp. b1-b2
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  • PSM volume 48 issue 9 Cover and Back matter

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    11 June 2018, pp. b1-b2
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Correspondence

  • Selective role for the COMT polymorphism in a trans-diagnostic compulsivity phenotype

  • Samuel R. Chamberlain, Jon E. Grant
  • Published online by Cambridge University Press:
    24 August 2018, pp. 2626-2627
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  • Background

    Impulsivity and compulsivity are central to understanding a range of psychiatric disorders but also to understanding the spectrum of normative human behavior. It was recently shown that separable latent phenotypes of impulsivity and compulsivity could be fractionated. The possible genetic contributions to these latent phenotypes have yet to be elicited. The catechol-o-methyl transferase (COMT) Val158Met polymorphism (rs4680) regulates cortical dopamine degradation and is a key area of interest in this context.

    Methods

    COMT Val158Met polymorphism status was obtained from a random subset (n = 258) of young adults from an established cohort, for whom latent phenotype scores were previously reported. Differences in latent phenotype scores were explored between COMT groups using analysis of variance (ANOVA) and post-hoc t tests.

    Results

    The Val-Val subgroup exhibited significantly elevated compulsivity scores compared to both other groups. Impulsivity scores did not differ significantly as a function of COMT Val158Met polymorphism status.

    Conclusions

    These results suggest that the COMT polymorphism, and by implication cortical dopamine degradation, influences the expression of a trans-diagnostic compulsivity phenotype, even accounting for possible confounding effects of impulsivity.

Back Cover (IBC, OBC) and matter

  • PSM volume 48 issue 10 Cover and Back matter

  • Published online by Cambridge University Press:
    13 June 2018, pp. b1-b2
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  • PSM volume 48 issue 2 Cover and Back matter

  • Published online by Cambridge University Press:
    20 December 2017, pp. b1-b2
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Front Cover (OFC, IFC) and matter

  • PSM volume 48 issue 12 Cover and Front matter

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    03 August 2018, pp. f1-f2
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Erratum

Correspondence

  • Addiction: a brief history of an idea

  • C.V. Haldipur
  • Published online by Cambridge University Press:
    19 February 2018, pp. 1395-1396
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Back Cover (IBC, OBC) and matter

  • PSM volume 48 issue 1 Cover and Back matter

  • Published online by Cambridge University Press:
    12 December 2017, pp. b1-b2
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  • PSM volume 48 issue 5 Cover and Back matter

  • Published online by Cambridge University Press:
    08 March 2018, pp. b1-b2
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Front Cover (OFC, IFC) and matter

  • PSM volume 48 issue 16 Cover and Front matter

  • Published online by Cambridge University Press:
    14 November 2018, pp. f1-f2
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Back Cover (IBC, OBC) and matter

  • PSM volume 48 issue 3 Cover and Back matter

  • Published online by Cambridge University Press:
    08 January 2018, pp. b1-b2
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  • PSM volume 48 issue 14 Cover and Back matter

  • Published online by Cambridge University Press:
    07 September 2018, pp. b1-b2
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  • PSM volume 48 issue 16 Cover and Back matter

  • Published online by Cambridge University Press:
    14 November 2018, pp. b1-b2
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Page 16 of 17