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Sensing of Oligopeptides Using Alternatively-Deposited Gold Nanorods for Surface-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry

Published online by Cambridge University Press:  22 February 2012

Masanori Fujii ,
Naotoshi Nakashima  and
Yasuro Niidome
Masanori Fujii
Affiliation:
Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan
Naotoshi Nakashima
Affiliation:
Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan World Premier International (WPI) Research Center, International Institute for Carbon-Neutral Energy Research (I2CNER), Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan JST-CREST, 5 Sanbancho, Chiyoda-ku, Tokyo 102-0075, Japan
Yasuro Niidome
Affiliation:
Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan World Premier International (WPI) Research Center, International Institute for Carbon-Neutral Energy Research (I2CNER), Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan
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Abstract

Gold nanorods (NRs) were fixed on an ITO plate and used for the Surface-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (SALDI-MS) of oligopeptides (angiotensin I). The SALDI-MS measurements had a high sensitivity to the angiotensin on the ITO plate on which isolated NRs were deposited. Angiotensin molecules in a very diluted solution (1 × 10-11 M) could be detected at m/z = 1297 with a good signal/noise ratio (S/N = 18). In contrast, alternatively deposited NR an ITO plate, which present broad surface plasmon bands, was found to be inactive for SALDI measurements.

Keywords

laser ablationmass spectroscopynanostructure
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1418: Symposium LL/MM – Gels and Biomedical Materials , 2012 , mrsf11-1418-mm03-25
Copyright
Copyright © Materials Research Society 2012

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