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Non-distorted visible light-absorbing thiol-PEGylated gold-coated superparamagnetic iron oxide nanoparticles–porphyrin conjugates and their inhibitory effects against nosocomial pathogens

Published online by Cambridge University Press:  28 October 2019

Bamidele M. Amos-Tautua ,
Olayemi J. Fakayode ,
Sandy van Vuuren ,
Sandile P. Songca  and
Oluwatobi S. Oluwafemi
Bamidele M. Amos-Tautua
Affiliation:
Department of Chemical Sciences (formerly Applied Chemistry), University of Johannesburg, P. O. Box 17011, Doornfontein 2028, Johannesburg, South Africa Centre for Nanomaterials Science Research, University of Johannesburg, Johannesburg, South Africa
Olayemi J. Fakayode
Affiliation:
Department of Chemical Sciences (formerly Applied Chemistry), University of Johannesburg, P. O. Box 17011, Doornfontein 2028, Johannesburg, South Africa Centre for Nanomaterials Science Research, University of Johannesburg, Johannesburg, South Africa
Sandy van Vuuren
Affiliation:
Department of Pharmacy and Pharmacology, University of the Witwatersrand, Parktown 2193, Johannesburg, South Africa
Sandile P. Songca
Affiliation:
Department of Chemistry, University of KwaZulu-Natal, Private Bag X 54001, Durban4000, South Africa
Oluwatobi S. Oluwafemi*
Affiliation:
Department of Chemical Sciences (formerly Applied Chemistry), University of Johannesburg, P. O. Box 17011, Doornfontein 2028, Johannesburg, South Africa Centre for Nanomaterials Science Research, University of Johannesburg, Johannesburg, South Africa
*
Address all correspondence to Oluwatobi S. Oluwafemi at [email protected]
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Abstract

A low-cost synthesis approach was developed for the fabrication of four symmetric meso-substituted water-soluble thiolated polyethylene glycol gold-coated superparamagnetic iron oxide nanoparticles–porphyrin (p-hydroxyphenyl [THPP], 3,5-dimethoxyphenyl [TdMPP], 3-pyridyl[T-3-PyP], and 1-methylpyridinium-3-yl[T3-Py+P4I−]) conjugates to achieve materials with enhanced absorption and therapeutic properties. After evaluation of their antibacterial inhibition characteristics against four nocosomial pathogens (Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Enterococcus faecalis), THPP and TdMPP conjugates showed some remarkable minimum inhibitory concentration values of 0.104 and 0.625 mg/mL against E. coli and E. faecalis, respectively, making these materials to be alternative agents for the inhibition of these pathogens in the environmental and clinical fields.

Type
Research Letters
Information
MRS Communications , Volume 9 , Issue 4 , December 2019 , pp. 1335 - 1342
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Copyright
Copyright © Materials Research Society 2019

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