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The Role of Apoptosis in Myocyte Death During Cardiac Hypertrophy

Published online by Cambridge University Press:  02 July 2020

E.C. Goldsmith ,
J.G. Davis ,
X. Yan ,
B.H. ᒫorell ,
T.K. Borg  and
R.L. Price
E.C. Goldsmith
Affiliation:
Department of Developmental Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC, 29209
J.G. Davis
Affiliation:
Department of Developmental Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC, 29209
X. Yan
Affiliation:
Beth Israel Deaconess Medical Center, Harvard University, Boston, MA , 02215
B.H. ᒫorell
Affiliation:
Beth Israel Deaconess Medical Center, Harvard University, Boston, MA , 02215
T.K. Borg
Affiliation:
Department of Developmental Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC, 29209
R.L. Price
Affiliation:
Department of Developmental Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC, 29209
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Abstract

Apoptotic events can be the result of both cell anchorage-dependent and independent mechanisms. The term “anoikis” has been used to describe apoptotic events resulting from a lack of cell-ECM contact (Frisch and Francis, 1994). The integrin heterodimer α5β1 has been implicated in several systems as providing protection against apoptosis. Previous studies have demonstrated that the α5 integrin subunit is present only during cardiac development and conditions of cardiac hypertrophy and is not found in normal adult rat myocytes (Terracio et al., 1991). Cell anchorage-independent apoptosis can result from a variety of factors including biochemical and mechanical stimulus. Angiotensin II (Ang II) has been implicated as a modulator of myocyte apoptosis acting through the angiotensin II type I receptor (Kajstura et al., 1997). The role of a second Ang II receptor, angiotensin II type 2 receptor, has not been determined. The role of apoptosis in myocyte cell death during heart failure remains unclear.

Type
Apoptosis in Health and Disease: Techniques for Detection and Biological Importance (Organized by M. Watanabe)
Information
Microscopy and Microanalysis , Volume 7 , Issue S2: Proceedings: Microscopy & Microanalysis 2001, Microscopy Society of America 59th Annual Meeting, Microbeam Analysis Society 35th Annual Meeting, Long Beach, California August 5-9, 2001 , August 2001 , pp. 596 - 597
Copyright
Copyright © Microscopy Society of America 2001

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References

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