Hostname: page-component-586b7cd67f-dsjbd Total loading time: 0 Render date: 2024-11-23T07:54:35.330Z Has data issue: false hasContentIssue false
  • English
  • Français

The Expression Patterns of Semaphorin Genes 3b, 4a, 4f, and 6c in the Lymphoid Tissue of Mice Found Through in Situ Hybridization

Published online by Cambridge University Press:  02 July 2020

Sayeh Beheshti  and
David Matthes
Sayeh Beheshti
Affiliation:
Department of Biological Sciences, San Jose State University
David Matthes
Affiliation:
Department of Biological Sciences, San Jose State University
Get access

Abstract

The semaphorin family consists of a set of secreted and transmembrane proteins which contain a domain of approximately 500 amino acids called the semaphorin domain. The investigation of the role of semaphorin proteins in the nervous system has established them as chemorepellents of axons. Recent studies have identified the semaphorin proteins on the surface of cells in the immune system and in the genomes of two lytic viruses. These strongly suggest the possible involvement of the semaphorin proteins in the immune system. This study aims to understand the expression patterns of four semaphorin genes, Sema3B, Sema4A, Sema4F, and Sema6C in the lymphoid tissues of wild type mice. These proteins were chosen to represent the three subfamilies III, IV, and VI. The first family contains secreted proteins which have immunoglobulin domains (III), the second contains transmembrane proteins which have immunoglobulin domains (IV), and the third contains transmembrane proteins which do not have immunoglobulin domains (VI).

Type
Student Research Forum (Organized by R. Koch and Z. Mason)
Information
Microscopy and Microanalysis , Volume 7 , Issue S2: Proceedings: Microscopy & Microanalysis 2001, Microscopy Society of America 59th Annual Meeting, Microbeam Analysis Society 35th Annual Meeting, Long Beach, California August 5-9, 2001 , August 2001 , pp. 446 - 447
Copyright
Copyright © Microscopy Society of America 2001

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1 Kolodkin, A.L. et al, Cell. (1993) 1389-99CrossRefGoogle Scholar

2 Luo, Y. et al., Cell (1993) 217–227CrossRefGoogle Scholar

3 Matthes, D.J. et al., Cell (1995) 631–639CrossRefGoogle Scholar

4 Messersmith, E.K. et al., Neuron (1995) 949–959CrossRefGoogle Scholar

5 Spriggs, M.K., Curr Opin Immunol. (1999) 387-91CrossRefGoogle Scholar