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Comparative Analysis of Integrins and Cadherins as Cell Adhesion Molecules in Ascidian Sperm-Egg Interactions

Published online by Cambridge University Press:  02 July 2020

J. Lim ,
D. Leary  and
R. A. Koch
J. Lim
Affiliation:
Sperm Cell Biology and Gamete Ultrastructure Laboratory, Department of Biological Science, California State University, Fullerton92834-6850.
D. Leary
Affiliation:
Sperm Cell Biology and Gamete Ultrastructure Laboratory, Department of Biological Science, California State University, Fullerton92834-6850.
R. A. Koch
Affiliation:
Sperm Cell Biology and Gamete Ultrastructure Laboratory, Department of Biological Science, California State University, Fullerton92834-6850.
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Abstract

The earliest events in ascidian fertilization require sperm-egg recognition, sperm activation and penetration of the egg's protective barriers before sperm-egg fusion can occur. Species selective recognition is known to depend on recognition by sperm of egg N-acetylglucosamine sites. Binding to these sites triggers the defining event of ascidian sperm activation called mitochondrial translocation. in this process, the mitochondrion becomes anchored to follicles cells surrounding the egg and then rounds up, moves to the base of the head and translocates onto the tail. This actimmyosin-dependent process provides the force for penetration. Activation of myosin depends on a signaling pathway that leads to internal Ca2+ release and external Ca2+ entry.

In order for actimmyosin interactions to provide the force for penetration, the mitochondrion must be anchored to the outer surface of the egg complex. Presumably this anchor must also attach to actin filaments that serve as the track for the mitochondrial translocation process.

Type
Student Research Forum (Organized by R. Koch and Z. Mason)
Information
Microscopy and Microanalysis , Volume 7 , Issue S2: Proceedings: Microscopy & Microanalysis 2001, Microscopy Society of America 59th Annual Meeting, Microbeam Analysis Society 35th Annual Meeting, Long Beach, California August 5-9, 2001 , August 2001 , pp. 450 - 451
Copyright
Copyright © Microscopy Society of America 2001

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