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Investigation of the Migration/Proliferation Dichotomy and its Impact on Avascular Glioma Invasion

Published online by Cambridge University Press:  25 January 2012

K. Böttger ,
H. Hatzikirou ,
A. Chauviere  and
A. Deutsch
K. Böttger
Affiliation:
Center for Information Services and High-Performance Computing, Technische Universität Dresden, 01062 Dresden, Germany
H. Hatzikirou
Affiliation:
Department of Pathology, University of New Mexico, Albuquerque, NM 87131, USA
A. Chauviere*
Affiliation:
Department of Pathology, University of New Mexico, Albuquerque, NM 87131, USA
A. Deutsch
Affiliation:
Center for Information Services and High-Performance Computing, Technische Universität Dresden, 01062 Dresden, Germany
*
⋆ Corresponding author. E-mail: [email protected]
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Abstract

Gliomas are highly invasive brain tumors that exhibit high and spatially heterogeneous cell proliferation and motility rates. The interplay of proliferation and migration dynamics plays an important role in the invasion of these malignant tumors. We analyze the regulation of proliferation and migration processes with a lattice-gas cellular automaton (LGCA). We study and characterize the influence of the migration/proliferation dichotomy (also known as the “GO-or-Grow" mechanism) on avascular glioma invasion, in terms of invasion speed and width of the infiltration zone. We show that the invasive behavior of the (macroscopic) tumor colony is a highly complex phenomenon that cannot be extrapolated by the sole knowledge of the (microscopic) individual cell phenotype.

Keywords

avascular glioma invasioncell migrationproliferationGo-or-GrowLGCA
Type
Research Article
Information
Mathematical Modelling of Natural Phenomena , Volume 7 , Issue 1: Cancer modeling , 2012 , pp. 105 - 135
Copyright
© EDP Sciences, 2012

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