Hostname: page-component-7479d7b7d-8zxtt Total loading time: 0 Render date: 2024-07-08T15:51:10.177Z Has data issue: false hasContentIssue false
  • English
  • Français

Vertigo symptom scores and videonystagmographic examinations in recovered coronavirus disease 2019 patients

Published online by Cambridge University Press:  22 March 2023

E Cekic Open the ORCID record for E Cekic [Opens in a new window]  and
S Uşaklıoğlu
E Cekic*
Affiliation:
Department of Otolaryngology, Health Science University, Haseki Training and Research Hospital, Istanbul, Turkey
S Uşaklıoğlu
Affiliation:
Department of Otolaryngology, Health Science University, Haseki Training and Research Hospital, Istanbul, Turkey
*
Author for correspondence: Dr E Cekic, Department of Otolaryngology, Health Science University, Haseki Training and Research Hospital, Uğur Mumcu Mah, Belediye Sk. No. 7, Sultangazi, Istanbul 34265, Turkey E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) may be among the viral agents that affect the audio-vestibular system. This study aimed to investigate vestibular symptoms and videonystagmographic examinations in recovered coronavirus disease 2019 (Covid-19) patients compared with the control group.

Method

The patients were evaluated with Vertigo Symptom Scale questionnaire and audiometric, tympanometric, stapedial reflex and videonystagmographic examinations.

Results

A total of 92 of the patients in the coronavirus disease 2019 patients group and 25 of the volunteers in the control group were included in the study. The mean Vertigo Symptom Scale score was found to be significantly higher (p < 0.001) in the coronavirus disease 2019 group. Furthermore, one of the hospitalised patients was diagnosed with vestibular neuritis.

Conclusion

The vestibular system may also be affected in some coronavirus disease 2019 patients. Although this may be seen as dizziness in some patients, in rare cases it can cause severe issues, such as vestibular neuritis.

Keywords

VertigoCoronavirusHearing LossTinnitusInfectious Disease
Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 137 , Issue 8 , August 2023 , pp. 873 - 882
Copyright
Copyright © The Author(s), 2023. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Dr E Cekic takes responsibility for the integrity of the content of the paper

References

Guan, WJ, Ni, ZY, Hu, Y, Liang, WH, Ou, CQ, He, JX et al. China medical treatment expert group for Covid-19 clinical characteristics of Coronavirus Disease 2019 in China. N Engl J Med 2020 Apr 30;382:1708–20CrossRefGoogle Scholar
Wang, D, Hu, B, Hu, C, Zhu, F, Liu, X, Zhang, J et al. Clinical characteristics of 138 hospitalized patients with 2019 Novel Coronavirus-infected pneumonia in Wuhan, China. JAMA 2020;323:1061–9CrossRefGoogle ScholarPubMed
Agyeman, AA, Chin, KL, Landersdorfer, CB, Liew, D, Ofori-Asenso, R. Smell and taste dysfunction in patients with COVID-19: a systematic review and meta-analysis. Mayo Clin Proc 2020;95:1621–31CrossRefGoogle ScholarPubMed
Rocke, J, Hopkins, C, Philpott, C, Kumar, N. Is loss of sense of smell a diagnostic marker in COVID-19: a systematic review and meta-analysis. Clin Otolaryngol 2020;45:914–22CrossRefGoogle ScholarPubMed
Mao, L, Jin, H, Wang, M, Hu, Y, Chen, S, He, Q et al. Neurologic manifestations of hospitalized patients with Coronavirus disease 2019 in Wuhan, China. JAMA Neurol 1;77:683–90CrossRefGoogle Scholar
Almufarrij, I, Uus, K, Munro, KJ. Does coronavirus affect the audio-vestibular system? A rapid systematic review. Int J Audiol 2020;59:487–91CrossRefGoogle ScholarPubMed
De Luca, P, Scarpa, A, Ralli, M, Tassone, D, Simone, M, De Campora, L et al. Auditory disturbances and SARS-CoV-2 infection: brain inflammation or cochlear affection? systematic review and discussion of potential pathogenesis. Front Neurol 2021;12:707207CrossRefGoogle ScholarPubMed
Jafari, Z, Kolb, BE, Mohajerani, MH. Hearing loss, tinnitus, and dizziness in COVID-19: a systematic review and meta-analysis. Can J Neurol Sci 2022;49:184–95CrossRefGoogle ScholarPubMed
Cohen, BE, Durstenfeld, A, Roehm, PC. Viral causes of hearing loss: a review for hearing health professionals. Trends Hear 2014;18:2331216514541361Google ScholarPubMed
Young, YH. Contemporary review of the causes and differential diagnosis of sudden sensorineural hearing loss. Int J Audiol 2020;59:243–53CrossRefGoogle ScholarPubMed
Meinhardt, J, Radke, J, Dittmayer, C, Franz, J, Thomas, C, Mothes, R et al. Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19. Nat Neurosci 2021;24:168–75CrossRefGoogle ScholarPubMed
de Melo, GD, Lazarini, F, Levallois, S, Hautefort, C, Michel, V, Larrous, F et al. COVID-19-related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters. Sci Transl Med 2021;13:eabf8396CrossRefGoogle ScholarPubMed
Chen, B, Jiang, C, Han, B, Guan, C, Fang, G, Yan, S et al. High prevalence of occult thrombosis in cases of mild/moderate COVID-19. Int J Infect Dis 2021;104:77–82CrossRefGoogle ScholarPubMed
Hanff, TC, Mohareb, AM, Giri, J, Cohen, JB, Chirinos, JA. Thrombosis in COVID-19. Am J Hematol 2020;95:1578–89CrossRefGoogle ScholarPubMed
Yanik, B, Külcü, DG, Kurtais, Y, Boynukalin, S, Kurtarah, H, Gökmen, D. The reliability and validity of the Vertigo Symptom Scale and the Vertigo Dizziness Imbalance questionnaires in a Turkish patient population with benign paroxysmal positional vertigo. J Vestib Res 2008;18:159–70CrossRefGoogle Scholar
Viola, P, Ralli, M, Pisani, D, Malanga, D, Sculco, D, Messina, L et al. Tinnitus and equilibrium disorders in COVID-19 patients: preliminary results. Eur Arch Otorhinolaryngol 2021;278:3725–30CrossRefGoogle ScholarPubMed
Karadaş, Ö, Öztürk, B, Sonkaya, AR. A prospective clinical study of detailed neurological manifestations in patients with COVID-19. Neurol Sci 2020;41:1991–5CrossRefGoogle ScholarPubMed
Chen, Q, Zheng, Z, Zhang, C, Zhang, X, Wu, H, Wang, J et al. Clinical characteristics of 145 patients with corona virus disease 2019 (COVID-19) in Taizhou, Zhejiang. China Infection 2020;48:543–51CrossRefGoogle ScholarPubMed
Chen, T, Wu, D, Chen, H, Yan, W, Yang, D, Chen, G et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ 2020;368:m1091CrossRefGoogle ScholarPubMed
Vacchiano, V, Riguzzi, P, Volpi, L, Tappatà, M, Avoni, P, Rizzo, G et al. Early neurological manifestations of hospitalized COVID-19 patients. Neurol Sci 2020;41:2029–31CrossRefGoogle ScholarPubMed
Wang, Z, Yang, B, Li, Q, Wen, L, Zhang, R. Clinical features of 69 cases with coronavirus disease 2019 in Wuhan, China. Clin Infect Dis 2020;71:769–77CrossRefGoogle ScholarPubMed
Özçelik Korkmaz, M, Eğilmez, OK, Özçelik, MA, Güven, M. Otolaryngological manifestations of hospitalised patients with confirmed COVID-19 infection. Eur Arch Otorhinolaryngol 2021;278:1675–85CrossRefGoogle ScholarPubMed
Gelfand, AE. Essentials of Audiology, 4th edn. New York: Thieme, 2016CrossRefGoogle Scholar
Hegemann, SCA, Wenzel, A. Diagnosis and treatment of vestibular neuritis/neuronitis or peripheral vestibulopathy (PVP)? Open questions and possible answers. Otol Neurotol 2017;38:626–31CrossRefGoogle ScholarPubMed
Malayala, SV, Raza, A. A case of COVID-19-induced vestibular neuritis. Cureus 2020;12:e8918Google ScholarPubMed
Mat, Q, Noël, A, Loiselet, L, Tainmont, S, Chiesa-Estomba, CM, Lechien, JR et al. Vestibular neuritis as clinical presentation of COVID-19. Ear Nose Throat J 2021:145561321995021Google ScholarPubMed
WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) working group, Sterne, JAC, Murthy, S, Diaz, JV, Slutsky, AS, Villar, J et al. Association between administration of systemic corticosteroids and mortality among critically ill patients with COVID-19: a meta-analysis. JAMA 2020;324:1330–41Google ScholarPubMed
Li, H, Yan, B, Gao, R, Ren, J, Yang, J. Effectiveness of corticosteroids to treat severe COVID-19: a systematic review and meta-analysis of prospective studies. Int Immunopharmacol 2021;100:108121CrossRefGoogle ScholarPubMed
Elibol, E. Otolaryngological symptoms in COVID-19 Eur Arch Otorhinolaryngol 2021;278:1233–6CrossRefGoogle ScholarPubMed
Freni, F, Meduri, A, Gazia, F, Nicastro, V, Galletti, C, Aragona, P, Galletti, C, Galletti, B, Galletti, F. Symptomatology in head and neck district in coronavirus disease (COVID-19): a possible neuroinvasive action of SARS-CoV-2. Am J Otolaryngol 2020;41:102612CrossRefGoogle ScholarPubMed
Degen, C, Lenarz, T, Willenborg, K. Acute profound sensorineural hearing loss after COVID-19 pneumonia. Mayo Clin Proc 2020;95:1801–3CrossRefGoogle ScholarPubMed
Karimi-Galougahi, M, Naeini, AS, Raad, N, Mikaniki, N, Ghorbani, J. Vertigo and hearing loss during the COVID-19 pandemic - is there an association? Acta Otorhinolaryngol Ital 2020;40:463–5CrossRefGoogle ScholarPubMed
Dror, AA, Kassis-Karayanni, N, Oved, A, Daoud, A, Eisenbach, N, Mizrachi, M et al. Auditory performance in recovered SARS-COV-2 patients. Otol Neurotol 2021;42:666–70CrossRefGoogle ScholarPubMed
Kılıc, O, Kalcioglu, MT, Cag, Y, Tuysuz, O, Pektas, E, Caskurlu, H et al. Could sudden senseurinoral hearing loss be the sole manifestation of COVID-19? An investigation of into SARS-CoV2 int he etiology of sudden sensorineural hearing loss. Int J Infect Dis 2020;97:208–11CrossRefGoogle Scholar
Jafari, Z, Copps, T, Hole, G, Kolb, BE, Mohajerani, MH. Noise damage accelerates auditory aging and tinnitus: a Canadian population-based study. Otol Neurotol 2020;41:1316–26CrossRefGoogle ScholarPubMed
Omidvar, S, Mahmoudian, S, Khabazkhoob, M, Ahadi, M, Jafari, Z. Tinnitus impacts on speech and non-speech stimuli. Otol Neurotol 2018;39:e921–8CrossRefGoogle ScholarPubMed
Benghanem, S, Mazeraud, A, Azabou, E, Chhor, V, Shinotsuka, CR, Claassen, J et al. Brainstem dysfunction in critically ill patients. Crit Care 2020;24:5CrossRefGoogle ScholarPubMed
Neri, S, Signorelli, S, Pulvirenti, D, Mauceri, B, Cilio, D, Bordonaro, F et al. Oxidative stress, nitric oxide, endothelial dysfunction and tinnitus. Free Radic Res 2006;40:615–18CrossRefGoogle ScholarPubMed
Masuda, M, Kanzaki, S, Minami, S, Kikuchi, J, Kanzaki, J, Sato, H et al. Correlations of inflammatory biomarkers with the onset and prognosis of idiopathic sudden sensorineural hearing loss. Otol Neurotol 2012;33:1142–50CrossRefGoogle ScholarPubMed
Hamming, I, Timens, W, Bulthuis, ML, Lely, AT, Navis, G, van Goor, H. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus A first step in understanding SARS pathogenesis. J Pathol 2004;203:631–7CrossRefGoogle ScholarPubMed
Netland, J, Meyerholz, DK, Moore, S, Cassell, M, Perlman, S. Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2. J Virol 2008;82:7264–75CrossRefGoogle ScholarPubMed
Kakuda, TN. Pharmacology of nucleoside and nucleotide reverse transcriptase inhibitor-induced mitochondrial toxicity. Clin Ther 2000;22:685–708CrossRefGoogle ScholarPubMed
Cianfrone, G, Pentangelo, D, Cianfrone, F, Mazzei, F, Turchetta, R, Orlando, MP et al. Pharmacological drugs inducing ototoxicity, vestibular symptoms and tinnitus: a reasoned and updated guide. Eur Rev Med Pharmacol Sci 2011;15:601–36Google ScholarPubMed