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Intestinal-type sinonasal adenocarcinoma: a sporadic case

Published online by Cambridge University Press:  29 June 2007

Andrej Böör
Affiliation:
Institute of Pathology, Medical Faculty, P. J. Safarik University, Kosice
Ivan Jurkovič
Affiliation:
Institute of Pathology, Medical Faculty, P. J. Safarik University, Kosice
Katarína Dudríková
Affiliation:
Departments of Pathology, Louis Pasteur University Hospital, Kosice, Slovak Republic
Vojtech Kavečanský
Affiliation:
The Department of Otorhinolaryngology, Louis Pasteur University Hospital, Kosice, Slovak Republic
Imrich Friedmann*
Affiliation:
Department of Pathology, Northwick Park Hospital, Harrow, UK
*
Address for correspondence: Professor I. Friedmann, 11 Hathaway Close, Stanmore, Middlesex HA7 3NR.

Abstract

A sporadic case of the intestinal-type sinonasal adenocarcinoma is described. The patient was a comparatively young 33-year-old woman employed as a senior biochemical scientific technologist for several years. The light microscopical pattern was that of a papillary-tubular adenocarcinoma with areas of more solid mucinous elements in the deeper parts of the neoplasm. The neoplasm had invaded the nasal septum and reached the left orbit invading the left ethmoidal sinus. The glands were lined by columnar cells with elongated spindle-shaped nuclei and the cells expressed cytokeratin, carcinoembryonic antigen (CEA), Chromogranin A, gastrin and serotonin but not neurone-specific enolase (NSE) nor synaptophysin. Neurosecretory granules were present. There was no history of wood dust inhalation and her exposure to chemicals is of some interest but had probably little or no role in the causation of this neoplasm.

Type
Pathology in Focus
Copyright
Copyright © JLO (1984) Limited 1996

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Footnotes

Presented at the Conference of the Czech and Slovak Society of Pathologists, Olomouc, Czech Republic on 15 September 1995.

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