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Tau accumulation in two patients with frontotemporal lobe degeneration showing different types of aphasia using 18F-THK-5351 positron emission tomography: a case report

Published online by Cambridge University Press:  08 November 2017

Masahiko Takaya ,
Kazunari Ishii ,
Chisa Hosokawa ,
Kazumasa Saigoh  and
Osamu Shirakawa
Masahiko Takaya*
Affiliation:
Department of Neuropsychiatry, Kindai University Faculty of Medicine, Osaka, Japan
Kazunari Ishii
Affiliation:
Department of Radiology, Kindai University Faculty of Medicine, Osaka, Japan
Chisa Hosokawa
Affiliation:
Department of Radiology, Kindai University Faculty of Medicine, Osaka, Japan
Kazumasa Saigoh
Affiliation:
Department of Neurology, Kindai University Faculty of Medicine, Osaka, Japan
Osamu Shirakawa
Affiliation:
Department of Neuropsychiatry, Kindai University Faculty of Medicine, Osaka, Japan
*
Correspondence should be addressed to: Masahiko Takaya, MD, PhD, Department of Neuropsychiatry, Kindai University Faculty of Medicine, 377-2, Onohigashi, Osakasayama, Osaka, 589–8511, Japan. Phone +81-72-366-0221. Email: [email protected].
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Abstract

Tau deposits in Alzheimer's disease and corticobasal syndrome have been reported using 18F-THK-5351 positron emission tomography (PET). To our knowledge, our study is the first to demonstrate tau deposits in patients with frontotemporal lobe degeneration (FTLD), using 18F-THK-5351 PET. This case report presents two patients, both of whom showed positive Tau deposition using 18F-THK-5351 PET. One patient was diagnosed with semantic variant primary progressive aphasia (PPA) and the other diagnosed with logopenic variant PPA. Our results suggest an association in the pathology of Alzheimer's disease, corticobasal syndrome, and FTLD, and could plan more effective clinical care in advance.

Keywords

Tau18F-THK-5351 PETfrontotemporal lobe degenerationsemantic dementialogopenic aphasia
Type
Case Report
Information
International Psychogeriatrics , Volume 30 , Issue 5: Issue Theme: Brain Imaging , May 2018 , pp. 641 - 646
Copyright
Copyright © International Psychogeriatric Association 2017 

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