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Antenatal survey for the seroprevalence of HTLV-1 infections in the West Midlands, England

Published online by Cambridge University Press:  19 October 2009

S. Nightingale ,
D. Orton ,
D. Ratcliffe ,
S. Skidmore ,
J. Tosswill  and
U. Desselberger
S. Nightingale
Affiliation:
Midland Centre for Neurosurgery and Neurology, Smethwick, West Midlands, B67 77X
D. Orton
Affiliation:
Regional Virus Laboratory, East Birmingham Hospital, Birmingham B9 5ST
D. Ratcliffe
Affiliation:
Regional Virus Laboratory, East Birmingham Hospital, Birmingham B9 5ST
S. Skidmore
Affiliation:
Regional Virus Laboratory, East Birmingham Hospital, Birmingham B9 5ST
J. Tosswill
Affiliation:
Virus Reference Laboratory, Central Public Health Laboratory, Colindale Avenue, London NW9 5HT
U. Desselberger
Affiliation:
Regional Virus Laboratory, East Birmingham Hospital, Birmingham B9 5ST
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Summary

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The sera of 3522 women who attended an antenatal clinic in Birmingham. England were tested anonymously for antibodies against HTLV-1. Samples from 5 women (0·14%) were positive, one serum showed indeterminate reactivity. Two of the women (0·06%) were born in the West Indies (of Afro-Caribbean ethnic origin), one (0·03%) in Africa (of African ethnic origin), and three (0·09%) were white Caucasian women born in the UK. Thus, HTLV-1 infection in pregnant women in the UK, though comparatively rare, is not negligible. As transmission of HTLV-1 to the newborn via breast milk has been observed and as seropositive mothers can be advised to refrain from breastfeeding or to treat their milk, the question of routine screening for HTLV-1 infection during antenatal care is discussed.

Type
Research Article
Information
Epidemiology & Infection , Volume 110 , Issue 2 , April 1993 , pp. 379 - 387
Copyright
Copyright © Cambridge University Press 1993

References

REFERENCES

1.Hinuma, Y., Nagata, K.Hanaoka, M., Nakai, M., Matsumoto, T., Kinoshita, K. et al. Adult Tcell leukaemia: Antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proe Natl Aead Sci USA 1981: 73: 6476–81.CrossRefGoogle Scholar
2.Sarin, PS, HTLV-1, adult T-cell leukaemia and tropical spastic paraparesis. Ann Neurol 1988; 23 suppl: S181–4.CrossRefGoogle Scholar
3.Vernant, JC, Maurs, L.Gessain, A.Barin, F., Gout, O., Deleporte, JM et al. , Endemic tropical spastic paraparesis associated with T-lymphotropie virus type I: a clinical and seroepidemiological study of 25 cases. Ann Neurol 1987: 21: 123–30.CrossRefGoogle Scholar
4.Osame, M., Matsumoto, M., Usuku, K.Izuino, S.Ijiehi, N.Ainitani, H. et al. Chronie Progressive myelopathy associated with elevated antibodies to human T-lymphotrophie type 1 and adult T-cell leukaemia cells. Ann Neurol 1987; 21: 117–22.CrossRefGoogle Scholar
5.Miyoshi, I.Taguchi, H.Fujishita, M.Niiya, K.Kitagawa, T.Ohtsuki, Y. et al. Asymptomatic type C virus carriers in the family of an adult T-cell leukaemia patient. Jpn J Cancer Res (Gann) 1982; 73: 339–40.Google Scholar
6.Kajiyama, W.Kashiwagi, S., Hiyashi, J.Nomura, H., Ikematsu, H.Okochi, K.Intrafamilial clustering of anti-ATLV-positive persons. Amer J Epidemiol 1986: 124: 800–6.Google Scholar
7.Rodgers-Johnson, P., Morgan, OSC, Mora, C.Sarin, P.Ceroni, M.Piccardo, P. et al. The role of HTLV-1 in tropical spastic paraparesis in Jamaica. Ann Neurol 1988: 23 suppl: S121 6.CrossRefGoogle Scholar
8.Murphy, EL, Hanchard, B, Figueroa, JP, WN, Gibbs, WS, Lofters, Campbell, M et al. Modelling the risk of adult T cell leukemia/lymphoma in persons infected with human T lymphotropic virus type I. Int J Cancer 1989; 43: 250–3.CrossRefGoogle ScholarPubMed
9.Robert-Guroff, M, Clark, J, AP, Lanier, Beckman, G, Melbye, M, Ebbesen, P et al. Prevalence of HTLV-I in arctic regions. Int J Cancer 1985; 36: 651–5.CrossRefGoogle ScholarPubMed
10.Kazura, JW, Saxinger, WC, Wenger, J, Forsyth, K, Lederman, MM, Gillespie, JA et al. Epidemiology of human T-cell leukemia virus type I infection in East Sepik Province, Papua New Guinea. J Infect Dis 1987; 155: 1100–7.CrossRefGoogle ScholarPubMed
11.Asher, DM, Goudsmit, J, Pomeroy, K, Garruto, RM, Bakker, M, Ono, SG et al. Antibodies to HTLV-1 in populations of the South Western Pacific. J Med Virol 1988; 26: 339–51.CrossRefGoogle Scholar
12.Newton, M, Cruickshank, K, Miller, D, Dalgleish, A, Rudge, P, Clayden, S et al. Antibody to human T-lymphotrophic virus type 1 in West-Indian-born UK residents with spastic paraparesis. Lancet 1987; i: 415–6.Google Scholar
13.Dalgleish, A, Richardson, J, Matutes, E, Cruickshank, K, Newell, A, Sinclair, A et al. HTLV-1 infection in tropical spastic paraparesis: lymphocyte culture and serological response. AIDS Res Human Retroviruses 1988; 4: 475–85.Google Scholar
14.Mowbray, J, Mawson, S, Chawira, A, Skidmore, S, Boxall, E, Desselberger, U et al. Epidemiology of human T-cell leukaemia/lymphoma virus type 1 (HTLV-1) infections in a subpopulation of Afro-Caribbean origin in England. J Med Virol; 1989: 29: 289–95.Google Scholar
15.Kajiyama, W, Kashiwagi, S, Ikematsu, H, Hayashi, J, Nomura, H, Okochi, K.Intrafamilial transmission of adult T cell leukemia virus. J Infect Dis 1986; 154: 851–7.Google Scholar
16.Blattner, WA, Nomura, A, Clark, JW, Ho, GYF, Nakao, Y, Gallo, R et al. Modes of transmission and evidence for viral latency from studies of human T-cell lymphotropic virus type 1 in Japanese migrant populations in Hawaii. Proc Natl Acad Sci USA 1986; 83: 4895–8.Google Scholar
17.Sato, H, Okochi, K.Transmission of human T cell leukemia virus (HTLV-I) by blood transfusion: demonstration of proviral DNA in recipients' blood lymphocytes. Int J Cancer 1986; 37: 397–400.CrossRefGoogle ScholarPubMed
18.Public Health Service Working Group. Licensure of screening tests for antibody to human T-lymphotropic virus type I. MMWR 1988; 37: 736–47.Google Scholar
19.Sugiyama, H, Doi, H, Yamaguchi, K., Tsuji, Y, Miyamoto, T, Hino, S.Significance of postnatal mother-to-child transmission of human T-lymphotropic virus type 1 on the development of adult T-cell leukemia/lymphoma. J Med Virol 1986; 20: 243–60.CrossRefGoogle ScholarPubMed
20.Hino, S.HTLV-1 infection: Milk-borne infection as the major transmission pathway for peculiar endemia. Asian Med J 1989; 32: 239–45.Google Scholar
21.Tsuji, J, Doi, H, Yamabe, T, Ishimaru, T, Miyamoto, T, Hino, S.Prevention of mother-tochild transmission of human T-lymphotropic virus type I. Paediatrics 1990; 86: 11–7.Google Scholar
22.Saji, F, Ohashi, K, Tokugawa, Y, Kamiura, S, Azuma, C, Tanizawa, O.Perinatal infection of human T-lymphotropic virus type I, the etiologic virus of adult T-cell leukaemia/Iymphoma. Cancer 1990; 66: 1933–7.3.0.CO;2-5>CrossRefGoogle Scholar
23.Yamanouchi, K, Kinoshita, K, Moriuchi, R, Katamine, S, Amagasaki, T, Ikeda, S et al. Oral transmission of human T-cell leukaemia virus type-1 into a common marmoset (Callithrix jacchus) as an experimental model for milk-borne transmission. Jpn J Cancer Res (Gann) 1985; 76: 481–7.Google Scholar
24.Hino, S, Doi, H, Yoshikuni, H, Sugiyama, H, Ishimara, T, Yamabe, T et al. HTLV-1 carrier mothers with high titer antibody are at high risk as a source of infection. Jpn J Cancer Res (Gann) 1987; 78: 1156–8.Google Scholar
25.Hino, S, Sugiyama, H, Doi, H, Ishimaru, T, Yamabe, T, Tsuji, Y et al. , Breaking the cycle of HTLV-1 transmission via carrier mother's milk. Lancet 1987; ii: 158–9.CrossRefGoogle Scholar
26.Yamato, K, Taguchi, H, Yoshimoto, S, Fujishita, M, Yameshita, M, Ohtsuki, Y et al. Inactivation of lymphocyte-transforming activity of human T-cell leukaemia virus type I by heat. Jpn J Cancer Res (Gann) 1980; 77: 13–5.Google Scholar
27.Ando, Y, Nakano, S, Saito, K, Shimamoto, I, Ichiko, M, Toyama, T et al. Prevention of HTLV-1 transmission through the breast milk by a freeze-drying process. Jpn J Cancer Res (Gann) 1986; 77: 974–7.Google Scholar
28.Elian, M, Nightingale, S, Dean, G.Multiple sclerosis among United Kingdom-born children of immigrants from the Indian subcontinent, Africa and the West Indies. J Neurol Neurosurg Psychiat 1990; 53: 906–11.CrossRefGoogle ScholarPubMed
29.JHC, Tosswill, AE, Adea, Peckhnm, C, PP, Mortimer, JN, Weber. Infection with human T cell Ieukaemia/lymphoma virus type I in patients attending an antenatal clinic in London. BMJ 1990; 301: 95–6.Google Scholar
30.JN, Weber, Banatvala, N, Clayden, S, MeAdam, KPWJ, Palmer, S, Moulsdale, H et al. HTLV-1 infection in Papua New Guinea: Evidence for serologic false positivitv. J Infect Dis 1989; 159: 1025–8.Google Scholar
31.Hartley, TM, Khabbaz, RF, Cannon, RO, Kaplan, JE, Lainnore, MD. Characterization of antibody reactivity to human T-cell lymphotropic virus types 1 and II using immunoblot and radioimmunoprecipitation assays. J Clin Microbiol 1990; 28: 646–50.CrossRefGoogle Scholar
32.WHO Working Group on Acquired Immunodeficiency Syndrome (AIDS). Proposed WHO criteria for interpreting results from Western blot assays for HIV-1, HIV-2 and HTLV-1/HTLV-11. Wkly Epidem Rec 1990; 65 (37): 261–3.Google Scholar
33.Tosswill, JHC, Parry, JV and Weber, JN, Application of screening and confirmatory assays for anti-HTLV-1/11 in UK populations. J Med Virol 1992; 36: 167–71.CrossRefGoogle Scholar
34.Nerurkar, VR, Miller, MA, Leon-Monzon, ME, Ajdukiewicz, AB, Jenkins, CL, Sanders, RC, Godee, MS et al. Failure to isolate human T cell lymphotropic virus type I and to detect variant-specific genomic sequences by polymerase chain reaction in Melanesians with indeterminate Western immunoblot. J Gen Virol 1992; 73: 1805–10.Google Scholar
35.Richardson, JH, Newell, AL, Newman, PK, Mani, KS, Rangan, G, Dalgleish, AG, HTLV-1 and neurological disease in South India. Lancet 1989; i: 1079.CrossRefGoogle Scholar
36.Gessain, A, Francis, H, Sonan, T, Giordano, C, Akani, F, Piquemal, M et al. HTLV-1 and tropical spastic paraparesis in Africa. Lancet 1986; ii: 698.CrossRefGoogle Scholar
37.Banatvala, JE, Chrystie, IL, Palmer, SJ, Kenney, A.Retrospective study of HIV. hepatitis B, and HTLV-1 infection at a London antenatal clinic. Lancet 1990: 335: 859–60.Google Scholar
38.Salker, R, Tosswill, JHC, Barbara, JAJ, Runganga, J, Contreras, M, Tedder, RS et al. , HTLV-1/11 antibodies in UK blood donors. Lancet 1990; 336: 317.CrossRefGoogle Scholar
39.Lo, KJ, Tsai, YT, Lee, SD, Wu, TC, Wang, YY, Chen, GH et al. , Immunoprophylaxis of infection with hepatitis B virus in infants born to hepatitis B surface antigen-positive carrier mothers. J Infect Dis 1985; 152: 817–22.Google Scholar
40.Wheeley, SMN, Boxall, EH, Tarlow, MJ, Gatrad, AR, Anderson, J, Bissenden, J et al. , Hepatitis B vaccine in the prevention of perinatally transmitted hepatitis B virus infection: Final report on a West Midlands pilot study. J Med Virol 1990; 30: 113–6.Google Scholar
41.Cruickshank, JK, Richardson, JH, Morganost, C, Porter, J, Klenerman, P, Knight, J et al. , Screening for prolonged incubation of HTLV-I infection in British and Jamaican relatives of British patients with tropical spastic paraparesis. B M J 1990; 300: 300–4.CrossRefGoogle ScholarPubMed
42.Kaplan, JE, Osame, M, Kubota, H, Igeta, H, Nishitani, H.Maeda, Y et al. The risk of development of HTLV-I-associated myelopathy/tropieal spastic paraparesis among persons infected with HTLV-I. J AIDS 1990; 3: 1090–101.Google ScholarPubMed
43.Weber, J.HTLV-I infection in Britain. B M J 1990: 301: 71–2.Google Scholar
44.Anonymous. HTLV-I -A screen too many? Lancet 1990; 336: 1161.CrossRefGoogle Scholar