Canadian Journal of Neurological Sciences: Volume 22 -

Bilateral Temporal Lobe MRI Changes in Uncomplicated Hypoglycemic Coma
B.F. Boeve, D.G. Bell, J.H. Noseworthy
Published online by Cambridge University Press:

18 September 2015, pp. 56-58
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We report bilateral temporal lobe MRI findings in a patient following an episode of prolonged hypoglycemia uncomplicated by coexisting anoxia, hypotension, acidosis, drug intoxication, infection, or status epilepticus. The MRI findings are discussed in relation to the experimental and human data on hypoglycemic neuronal injury.

Writer’s Cramp and Tremor Due to Brain Tumor
I. Milanov, D. Georgiev
Published online by Cambridge University Press:

18 September 2015, pp. 59-61
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Writer’s cramp is frequently associated with hand tremor and with other focal dystonias. Sometimes brain infarction, haemorrhage, arterio-venous malformations or tumors are found to cause symptomatic focal dystonias. A 44-year-old man came to our attention due to writer’s cramp of his right hand and postural 6-8 Hz tremor. About three months after the onset of the disease the tremor and dystonia disappeared, while a right hemiparesis gradually appeared. Cranial computed tomography showed a hypodense nonhomogeneous lesion in the left cerebral hemisphere parietally, that was assumed to represent a cystic tumor. The patient underwent craniotomy and the histological diagnosis revealed an astrocytoma (Grade II-III). In conclusion our findings confirm the common anatomical basis of symptomatic focal dystonia and tremor. Both can appear after disruption of the pathways within and adjacent to the basal ganglia.

Canadian Guidelines for the Development of Antidementia Therapies: a Conceptual Summary
Erich Mohr, Howard Feldman, Serge Gauthier
Published online by Cambridge University Press:

18 September 2015, pp. 62-72
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The magnitude of the problems faced by Canadian society as a result of an aging population has been identified. Perhaps the most important concern related to this greying of Canada is the increasing incidence of dementia and Alzheimer’s disease. Therapeutic options for these disorders have been limited to date. Advances in biotechnology and molecular biology will offer novel approaches to treatment. These and the expansion of more traditional therapeutic avenues require guidelines with the aim of optimizing their development.