When Auguste D. was about 52, her husband noticed she was acting oddly, misplacing things around the house and suspecting him of having an affair with the next-door neighbor. Her memory rapidly declined over the next year and her paranoia and delusions worsened. The year was 1901, and she was admitted to the Asylum for the Insane and Epileptic in Frankfurt, where she came under the care of Dr. Alois Alzheimer, a young German psychiatrist with an interest in trying to link neuropathological changes in the brain with psychiatric and neurological illnesses. At the time Auguste D. died in 1906, Dr. Alzheimer had moved to another position in Munich, but he was able to obtain her brain for pathological examination. Under the microscope, he saw dark particles between the nerve cells in the outer layers of the brain. He also saw a different type of smaller dark particles within the nerve cells, which were twisted in appearance.