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12 - My Experimental Life

Published online by Cambridge University Press:  12 November 2022

Daniel Gibbs
Affiliation:
Emeritus of Oregon Health and Science University
Teresa H. Barker
Affiliation:
Freelance journalist and author of scientific non-fiction
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Summary

Headlines make scientific breakthroughs seem sudden, but, in truth, the real advancement of science is more like the construction of a pyramid. Each block of the pyramid represents a hypothesis that attempts to explain an observation in nature that has been tested experimentally. Depending on the results of the experiment, the hypothesis is either confirmed, revised and tested again, or rejected. Each block adds to a new layer of the pyramid, each layer built on those below. No single study is likely to crack the code for an immediate Alzheimer’s cure, but each one contributes to our understanding in ways that I am confident will eventually lead to more effective treatment and prevention. Even if it’s not in time for me.

Clinical trials are the bricks and mortar of medical science, and if having Alzheimer’s means I’ve had to step away from any professional involvement with them, it also opened up a new opportunity to stay involved.

Type
Chapter
Information
A Tattoo on my Brain
A Neurologist's Personal Battle against Alzheimer's Disease
, pp. 83 - 90
Publisher: Cambridge University Press
Print publication year: 2023

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References

Chapter-references

Jack, CR, Wiste, HJ, Weigand, SD, et al. Age-specific population frequencies of cerebral β-amyloidosis and neurodegeneration among people with normal cognitive function aged 50–89 years: a cross-sectional study. Lancet Neurology 2014; 13:9971005; https://doi.org/10.1016/S1474-4422(14)70194-2 (public access version available at www.ncbi.nlm.nih.gov/pmc/articles/PMC4324499).CrossRefGoogle ScholarPubMed
La Joie, R, Visani, AV, Baker, SL, et al. Prospective longitudinal atrophy in Alzheimer’s disease correlates with the intensity and topography of baseline tau-PET. Science Translational Medicine 2020; eaau5732; https://doi.org/10.1126/scitranslmed.aau5732 (public access version available at www.ncbi.nlm.nih.gov/pmc/articles/PMC7035952).CrossRefGoogle Scholar
Sevigny, J, Chiao, P, Bussie`re, T, et al. The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease. Nature 2016; 537:5056; https://doi.org/10.1038/nature19323.CrossRefGoogle ScholarPubMed

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  • My Experimental Life
  • Daniel Gibbs, Emeritus of Oregon Health and Science University, Teresa H. Barker, Freelance journalist and author of scientific non-fiction
  • Book: A Tattoo on my Brain
  • Online publication: 12 November 2022
  • Chapter DOI: https://doi.org/10.1017/9781009330961.014
Available formats
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  • My Experimental Life
  • Daniel Gibbs, Emeritus of Oregon Health and Science University, Teresa H. Barker, Freelance journalist and author of scientific non-fiction
  • Book: A Tattoo on my Brain
  • Online publication: 12 November 2022
  • Chapter DOI: https://doi.org/10.1017/9781009330961.014
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • My Experimental Life
  • Daniel Gibbs, Emeritus of Oregon Health and Science University, Teresa H. Barker, Freelance journalist and author of scientific non-fiction
  • Book: A Tattoo on my Brain
  • Online publication: 12 November 2022
  • Chapter DOI: https://doi.org/10.1017/9781009330961.014
Available formats
×