Although a disease-altering treatment has yet to be found, our understanding of Alzheimer's disease (AD) genetics and neurobiology has increased exponentially over the past few decades, as has our ability to detect Alzheimer's pathology using various biomarkers. In this chapter, we will review the genetic, pathological, and behavioral features of Alzheimer's disease and discuss how the use of biomarkers for the detection of AD has potentially opened up new avenues for the prevention (or possible reversal) of AD. Given the current absence of an effective pharmacological treatment, we will also describe how lifestyle may impact one's risk for developing AD and review potential strategies for reducing AD risk as well as reviewing currently available treatments aimed at ameliorating some of the symptoms of AD. For strategies to ameliorate some of the secondary behavioral symptoms often associated with Alzheimer's disease and other dementias, the reader is directed to Chapter 5.