Skip to main content Accessibility help
×
Hostname: page-component-78c5997874-m6dg7 Total loading time: 0 Render date: 2024-11-16T16:10:12.520Z Has data issue: false hasContentIssue false

Chapter 1 - Renal Physiology

from Section 1 - Physiology

Published online by Cambridge University Press:  19 May 2018

Kate Bramham
Affiliation:
King’s College Hospital, London
Matt Hall
Affiliation:
Nottingham University Hospitals
Catherine Nelson-Piercy
Affiliation:
Guys's & St Thomas's NHS Foundation Trust, London
Get access

Summary

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2018

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Brown, MA. Urinary tract dilatation in pregnancy. Am J Obstet Gynecol. 1990;164:641643.Google Scholar
Conrad, KP , GL, Lindheimer, MD. The kidney in normal pregnancy and preeclampsia. In Lindheimer, M, Roberts, JM, Cunningham, FG, ed. Chesley’s hypertensive disorders in pregnancy. San Diego, CA: Elsevier Inc.; 2009:297334.CrossRefGoogle Scholar
Dunlop, W. Investigations into the influence of posture on renal plasma flow and glomerular filtration rate during late pregnancy. British journal of obstetrics and gynaecology. 1976;83:1723.Google Scholar
Sims, EA, Krantz, KE. Serial studies of renal function during pregnancy and the puerperium in normal women. J Clin Invest. 1958;37:17641774.Google Scholar
Assali, NS, Dignam, WJ, Dasgupta, K. Renal function in human pregnancy: Effects of venous pooling on renal hemodynamics and water, electrolyte, and aldosterone excretion during gestation. The journal of laboratory and clinical medicine. 1959;54:394408.Google ScholarPubMed
Davison, JM, Noble, MC. Serial changes in 24 hour creatinine clearance during normal menstrual cycles and the first trimester of pregnancy. British journal of obstetrics and gynaecology. 1981;88:1017.CrossRefGoogle ScholarPubMed
Paaby, P, Brochner-Mortensen, J, Fjeldborg, P, Raffn, K, Larsen, CE, Moller-Petersen, J. Endogenous overnight creatinine clearance compared with 51cr-edta clearance during the menstrual cycle. Acta medica Scandinavica. 1987;222:281284.CrossRefGoogle ScholarPubMed
Davison, JM, Dunlop, W, Ezimokhai, M. 24-hour creatinine clearance during the third trimester of normal pregnancy. British journal of obstetrics and gynaecology. 1980;87:106109.CrossRefGoogle ScholarPubMed
Roberts, M, Lindheimer, MD, Davison, JM. Altered glomerular permselectivity to neutral dextrans and heteroporous membrane modeling in human pregnancy. Am J Physiol. 1996;270:F338343.Google Scholar
Milne, JE, Lindheimer, MD, Davison, JM. Glomerular heteroporous membrane modeling in third trimester and postpartum before and during amino acid infusion. Am J Physiol Renal Physiol. 2002;282:F170175.CrossRefGoogle ScholarPubMed
Sturgiss, SN, Wilkinson, R, Davison, JM. Renal reserve during human pregnancy. Am J Physiol. 1996;271:F1620.Google ScholarPubMed
Smith, MC, Ward, MK, Sturgiss, SN, Milne, JE, Davison, JM. Sex and the pregnant kidney: Does renal allograft gender influence gestational renal adaptation in renal transplant recipients? Transplant Proc. 2004;36:26392642.CrossRefGoogle ScholarPubMed
Baylis, C. The mechanism of the increase in glomerular filtration rate in the twelve-day pregnant rat. J Physiol. 1980;305:405414.Google Scholar
Smith, MC, Murdoch, AP, Danielson, LA, Conrad, KP, Davison, JM. Relaxin has a role in establishing a renal response in pregnancy. Fertility and sterility. 2006;86:253255.CrossRefGoogle Scholar
Conrad, KP, Davison, JM. The renal circulation in normal pregnancy and preeclampsia: Is there a place for relaxin? Am J Physiol Renal Physiol. 2014;306:F11211135.CrossRefGoogle Scholar
Smith, MC, Danielson, LA, Conrad, KP, Davison, JM. Influence of recombinant human relaxin on renal hemodynamics in healthy volunteers. J Am Soc Nephrol. 2006;17:31923197.CrossRefGoogle ScholarPubMed
McGuane, JT, Danielson, LA, Debrah, JE, Rubin, JP, Novak, J, Conrad, KP. Angiogenic growth factors are new and essential players in the sustained relaxin vasodilatory pathway in rodents and humans. Hypertension. 2011;57:11511160.CrossRefGoogle ScholarPubMed
Matthews, BF, Taylor, DW. Effects of pregnancy on inulin and para-aminohippurate clearances in the anaesthetized rat. J Physiol. 1960;151:385389.CrossRefGoogle ScholarPubMed
Strevens, H, Wide-Swensson, D, Hansen, A, Horn, T, Ingemarsson, I, Larsen, S, Willner, J, Olsen, S. Glomerular endotheliosis in normal pregnancy and pre-eclampsia. BJOG. 2003;110:831836.Google Scholar
Sheehan, HL. Renal morphology in preeclampsia. Kidney Int. 1980;18:241252.Google Scholar
Higby, K, Suiter, CR, Phelps, JY, Siler-Khodr, T, Langer, O. Normal values of urinary albumin and total protein excretion during pregnancy. Am J Obstet Gynecol. 1994;171:984989.Google Scholar
Taylor, AA, Davison, JM. Albumin excretion in normal pregnancy. Am J Obstet Gynecol. 1997;177:15591560.Google ScholarPubMed
Wright, A, Steele, P, Bennett, JR, Watts, G, Polak, A. The urinary excretion of albumin in normal pregnancy. British journal of obstetrics and gynaecology. 1987;94:408412.Google Scholar
Baweja, S, Kent, A, Masterson, R, Roberts, S, McMahon, LP. Prediction of pre-eclampsia in early pregnancy by estimating the spot urinary albumin: Creatinine ratio using high-performance liquid chromatography. BJOG. 2011;118:11261132.CrossRefGoogle ScholarPubMed
Cheung, CK, Lao, T, Swaminathan, R. Urinary excretion of some proteins and enzymes during normal pregnancy. Clinical chemistry. 1989;35:19781980.Google Scholar
Kronborg, C, Vittinghus, E, Allen, J, Knudsen, UB. Excretion patterns of large and small proteins in pre-eclamptic pregnancies. Acta Obstet Gynecol Scand. 2011;90:897902.Google Scholar
Davison, JM, Hytten, FE. The effect of pregnancy on the renal handling of glucose. British journal of obstetrics and gynaecology. 1975;82:374381.CrossRefGoogle ScholarPubMed
Dunlop, W, Davison, JM. The effect of normal pregnancy upon the renal handling of uric acid. British journal of obstetrics and gynaecology. 1977;84:1321.CrossRefGoogle ScholarPubMed
Thangaratinam, S, Ismail, KM, Sharp, S, Coomarasamy, A, Khan, KS, Tests in prediction of pre-eclampsia severity review g: Accuracy of serum uric acid in predicting complications of pre-eclampsia: A systematic review. BJOG. 2006;113:369378.Google Scholar
Lindheimer, MD, Davison, JM. Osmoregulation, the secretion of arginine vasopressin and its metabolism during pregnancy. European journal of endocrinology / European Federation of Endocrine Societies. 1995;132:133143.Google Scholar
Duvekot, JJ, Cheriex, EC, Pieters, FA, Menheere, PP, Schouten, HJ, Peeters, LL. Maternal volume homeostasis in early pregnancy in relation to fetal growth restriction. Obstet Gynecol. 1995;85:361367.CrossRefGoogle ScholarPubMed
Lindheimer, MD, Barron, WM, Davison, JM. Osmoregulation of thirst and vasopressin release in pregnancy. Am J Physiol. 1989;257:F159169.Google Scholar
Chapman, AB, Abraham, WT, Zamudio, S, Coffin, C, Merouani, A, Young, D, Johnson, A, Osorio, F, Goldberg, C, Moore, LG, Dahms, T, Schrier, RW. Temporal relationships between hormonal and hemodynamic changes in early human pregnancy. Kidney Int. 1998;54:20562063.Google Scholar
Sherwood, OD. Relaxin. In: Knobil, E , NJ, ed. The physiology of pregnancy. New York: Raven Press; 1994:8611009.Google Scholar
Gant, NF, Whalley, PJ, Everett, RB, Worley, RJ, MacDonald, PC. Control of vascular reactivity in pregnancy. Am J Kidney Dis. 1987;9:303307.CrossRefGoogle ScholarPubMed
Castro, LC, Hobel, CJ, Gornbein, J. Plasma levels of atrial natriuretic peptide in normal and hypertensive pregnancies: A meta-analysis. Am J Obstet Gynecol. 1994;171:16421651.CrossRefGoogle ScholarPubMed
Ohara, M, Martin, PY, Xu, DL, St John, J, Pattison, TA, Kim, JK, Schrier, RW. Upregulation of aquaporin 2 water channel expression in pregnant rats. J Clin Invest. 1998;101:10761083.CrossRefGoogle ScholarPubMed
Davison, JM, Shiells, EA, Philips, PR, Lindheimer, MD. Influence of humoral and volume factors on altered osmoregulation of normal human pregnancy. Am J Physiol. 1990;258:F900907.Google Scholar
Barron, WM, Durr, JA, Schrier, RW, Lindheimer, MD. Role of hemodynamic factors in osmoregulatory alterations of rat pregnancy. Am J Physiol. 1989;257:R909916.Google ScholarPubMed
West, CA, Han, W, Li, N, Masilamani, SM. Renal epithelial sodium channel is critical for blood pressure maintenance and sodium balance in the normal late pregnant rat. Experimental physiology. 2014;99:816823.CrossRefGoogle ScholarPubMed
West, CA, McDonough, AA, Masilamani, SM, Verlander, JW, Baylis, C. The renal sodium chloride co-transporter, ncc, is unchanged in the mid pregnant rat and decreased in the late pregnant rat despite avid renal sodium retention. Am J Physiol Renal Physiol. 2015;ajprenal 00147 02015.CrossRefGoogle Scholar
Ehrlich, EN, Lindheimer, MD. Effect of administered mineralocorticoids or acth in pregnant women: Attenuation of kaliuretic influence of mineralocorticoids during pregnancy. J Clin Invest. 1972;51:13011309.CrossRefGoogle ScholarPubMed
West, C, Qiu, E, Baylis, C, Gumz, M. [312-pos]: Mechanisms of renal potassium retention during late pregnancy. Pregnancy hypertension. 2015;5:153.Google Scholar
Smith, MC, Moran, P, Ward, MK, Davison, JM. Assessment of glomerular filtration rate during pregnancy using the mdrd formula. BJOG. 2008;115:109112.Google Scholar
Alper, AB, Yi, Y, Rahman, M, Webber, LS, Magee, L, Von Dadelszen, P, Pridjian, G, Aina-Mumuney, A, Saade, G, Morgan, J, Nuwayhid, B, Belfort, M, Puschett, J. Performance of estimated glomerular filtration rate prediction equations in preeclamptic patients. Am J Perinatol. 28:425430.CrossRefGoogle Scholar
Davison, JM, Hytten, FE. Glomerular filtration during and after pregnancy. The Journal of obstetrics and gynaecology of the British Commonwealth. 1974;81:588595.Google Scholar
Moodley, J, Gangaram, R, Khanyile, R, Ojwang, PJ. Serum cystatin c for assessment of glomerular filtration rate in hypertensive disorders of pregnancy. Hypertens Pregnancy. 2004;23:309317.Google Scholar
Baylis, C. Renal disease in gravid animal models. Am J Kidney Dis. 1987;9:350353.Google Scholar
Baylis, C, Wilson, CB. Sex and the single kidney. Am J Kidney Dis. 1989;13:290298.CrossRefGoogle ScholarPubMed
Baylis, C. Immediate and long-term effects of pregnancy on glomerular function in the shr. Am J Physiol. 1989;257:F11401145.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×