This chapter first outlines different models of regional cooperation in competition policy and law from around the world, and argues that deep and effective regional cooperation in competition law enforcement does not necessarily require a binding regional competition law regime and a regional competition enforcement body with supranational powers. The chapter then studies three major challenges faced by the ASEAN member states in the development of a regional competition law, namely differences between levels of economic development of the member states, different political traditions and legal systems and, differences in competition culture of the member states. This review includes a discussion on the suitability of the solutions tailored by other regional blocs for similar challenges. The chapter concludes with a summary of findings and recommendations for the ASEAN region.