Benedict XII, as is well known, made a far greater contribution than did John XXII to establishing the papacy on the banks of the Rhône. A few months after acceding to the papal throne, he started the construction of a new pontifical palace, larger than the previous one and more appropriate for developments within the Curia. He then ordered that the Church archives, which at that time were still kept in Assisi, be transferred to Avignon. Finally, in 1337, he abandoned the effort to return to Rome, gradually yielding to the arguments of those in the Curia who claimed that the situation in Italy and Rome was too serious and too dangerous. Throughout his pontificate Italy was, therefore, a field of intervention rather than familiar ground, given that the pope never had the opportunity to go there.

Since the late nineteenth and early twentieth century, with the opening of the Vatican Archives to researchers, Benedict XII's relations with the peninsula have attracted the interest of historians such as Heinrich Otto, Guillaume Mollat, Gerolamo Biscaro, Giovanni Tabacco, and Eugenio Duprè Theseider. This is not surprising, since Italian matters were among the major items of expenditure for the popes of the fourteenth century.

Benedict XII inherited a particularly explosive situation in Italy, rent by factional struggles and where political regimes were being transformed and maturing.