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Case 18 - Laryngeal Squamous Cell Carcinoma and Synchronous Oropharyngeal HPV-Related Carcinoma with Nodal Metastases

Published online by Cambridge University Press:  19 November 2019

Alessandro Franchi
Affiliation:
Università degli Studi di Firenze, Italy
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Summary

An 80-year-old male presented with a 3-month history of hoarseness. He had been a heavy cigarette smoker for 40 years, and 5 years earlier, a laryngeal biopsy had shown hyperplasia of the squamous epithelium, with no evidence of dysplasia. Flexible fiber-optic laryngoscopy demonstrated a keratotic vegetating lesion involving both vocal cords and the anterior commissure. Clinical examination revealed adenopathy in neck level III on the right side. A CT scan was performed, revealing a glottic neoplasm involving both true vocal cords and the anterior commissure, without invasion of the posterior commissure (Figure 1). The lesion apparently involved the right false vocal cord in the coronal plane, but no invasion of the paraglottic spaces, thyroid, and arytenoid cartilages was evident. Cervical lymphadenopathy with cystic appearance was detected in level III of the right lateral cervical chain in the MRI imaging (Figure 2). The patient underwent total laryngectomy with bilateral neck dissection.

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Publisher: Cambridge University Press
Print publication year: 2019

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References

Morris, LG, Sikora, AG, Patel, SG, Hayes, RB, Ganly, I. Second primary cancers after an index head and neck cancer: subsite-specific trends in the era of human papillomavirus-associated oropharyngeal cancer. J Clin Oncol. 2011;29:739746.CrossRefGoogle ScholarPubMed
Diaz, DA, Reis, IM, Weed, DT, Elsayyad, N, Samuels, M, Abramowitz, MC. Head and neck second primary cancer rates in the human papillomavirus era: a population-based analysis. Head Neck. 2016 Apr;38(Suppl 1):E873E883.CrossRefGoogle Scholar
Martel, M, Alemany, L, Taberna, M, Mena, M, Tous, S, Bagué, S, et al. The role of HPV on the risk of second primary neoplasia in patients with oropharyngeal carcinoma. Oral Oncol. 2017;64:3743.CrossRefGoogle ScholarPubMed
Jain, KS, Sikora, AG, Baxi, SS, Morris, LG. Synchronous cancers in patients with head and neck cancer: risks in the era of human papillomavirus-associated oropharyngeal cancer. Cancer. 2013;119:18321837.CrossRefGoogle ScholarPubMed
Xu, CC, Biron, VL, Puttagunta, L, Seikaly, H. HPV status and second primary tumours in oropharyngeal squamous cell carcinoma. J Otolaryngol Head Neck Surg. 2013;42:36.CrossRefGoogle ScholarPubMed
Thavaraj, S, Stokes, A, Mazuno, K, Henley-Smith, R, Suh, YE, Paleri, V, et al. Patients with HPV-related tonsil squamous cell carcinoma rarely harbour oncogenic HPV infection at other pharyngeal sites. Oral Oncol. 2014;50:241246.CrossRefGoogle ScholarPubMed
Begum, S, Cao, D, Gillison, M, Zahurak, M, Westra, WH. Tissue distribution of human papillomavirus 16 DNA integration in patients with tonsillar carcinoma. Clin Cancer Res. 2005;11:56945699.CrossRefGoogle ScholarPubMed
McGovern, SL, Williams, MD, Weber, RS, Sabichi, A, Chambers, MS, Martin, JW, et al. Three synchronous HPV-associated squamous cell carcinomas of Waldeyer’s ring: case report and comparison with Slaughter’s model of field cancerization. Head Neck. 2010;32:11181124.CrossRefGoogle ScholarPubMed
Lewis, JS Jr. Morphologic diversity in human papillomavirus-related oropharyngeal squamous cell carcinoma: catch me if you can! Mod Pathol. 2017;30:S44S53.CrossRefGoogle Scholar

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