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Chapter 16 - Antiphospholipid Syndrome

from Section 6 - Thrombophilia and Fetal Loss

Published online by Cambridge University Press:  01 February 2018

By
Sue Pavord ,
Bethan Myers ,
Savino Sciascia  and
Beverley Hunt
Edited by
Sue Pavord  and
Beverley Hunt
Sue Pavord
Affiliation:
University of Oxford
Beverley Hunt
Affiliation:
King's College London
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The Obstetric Hematology Manual , pp. 177 - 188
Publisher: Cambridge University Press
Print publication year: 2018

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References

Miyakis, S, Lockshin, MD, Atsumi, T et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). Journal of Thrombosis and Hemostasis 2006; 4: 295–306.Google Scholar
McMahon, MA, Keogan, M, O’Connell, P, Kearns, G. The prevalence of antiphospholipid antibody syndrome among systemic lupus erythematosus patients. Irish Medical Journal 2006; 99: 296–298.Google Scholar
Noori, AS, Jassim, NA, Gorial, FI. Prevalence of antiphospholipid antibodies in sample of Iraqi patients with systemic lupus erythematosus: a cross sectional study. American Journal of Clinical Medicine Research 2013; 1: 61–64.Google Scholar
Galli, M, Luciani, D, Bertolini, G, Barbui, T. Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: a systematic review of the literature. Blood 2003; 101: 1827–1832.CrossRefGoogle ScholarPubMed
Pengo, V, Ruffatti, A, Legnani, C et al. Incidence of a first thromboembolic event in asymptomatic carriers of high-risk antiphospholipid antibody profile: a multicenter prospective study. Blood 2011; 118(17): 4714–4718.CrossRefGoogle ScholarPubMed
Meroni, PL, Borghi, MO, Raschi, E, Tedesco, F. Pathogenesis of antiphospholipid syndrome: understanding the antibodies. Nature Reviews Rheumatology 2011; 7(6): 330–339.Google Scholar
Girardi, G, Redecha, P, Salmon, JE. Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation. Nature Medicine 2004; 10: 1222–1226.Google Scholar
Wilson, WA, Gharavi, AE, Koike, T et al. International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: report of an international workshop. Arthritis and Rheumatism 1999; 42: 1309–1311.3.0.CO;2-F>CrossRefGoogle ScholarPubMed
Cervera, R, Piette, JC, Font, J et al. Euro-Phospholipids Project Group. Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients. Arthritis and Rheumatism 2002; 46: 1019–1027.CrossRefGoogle Scholar
Asherson, RA, Khamashta, MA, Ordi-Ros, J et al. The “primary” antiphospholipid syndrome: major clinical and serological features. Medicine (Baltimore) 1989; 68: 366–374.CrossRefGoogle Scholar
Yetman, DL, Kutteh, WH. Antiphospholipid antibody panels and recurrent pregnancy loss: prevalence of anticardiolipin antibodies compared with other antiphospholipid antibodies. Fertility and Sterility 1996; 66: 540–546.Google Scholar
Rai, RS, Clifford, K, Cohen, H, Regan, L. High prospective fetal loss rate in untreated pregnancies of women with recurrent miscarriage and antiphospholipid antibodies. Human Reproduction 1995; 10: 3301–3304.CrossRefGoogle ScholarPubMed
Dreyfus, M, Hedelin, G, Kutnahorsky, R et al. Antiphospholipid antibodies and preeclampsia: a case-control study. Obstetrics and Gynecology 2001; 97: 29–34.Google ScholarPubMed
Diz-Küçükkaya, R, Hacihanefioglu, A, Yenerel, M et al. Antiphospholipid antibodies and antiphospholipid syndrome in patients presenting with immune thrombocytopenic purpura: a prospective cohort study. Blood 2001; 98: 1760–1764.CrossRefGoogle ScholarPubMed
Brandt, JT, Triplett, DA, Alving, B, Scharrer, I. Criteria for the diagnosis of lupus anticoagulants: an update. On behalf of the Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardization Committee of the ISTH. Thrombosis and Hemostasis 1995; 74: 1185–1190.Google Scholar
Harris, EN, Pierangeli, SS. Revisiting the anticardiolipin test and its standardization. Lupus 2002; 11: 269–275.CrossRefGoogle ScholarPubMed
Cowchock, FS, Reece, EA, Balaban, D et al. Repeated fetal losses associated with antiphospholipid antibodies: a collaborative randomised trial comparing prednisone with low-dose heparin treatment. American Journal of Obstetrics and Gynecology 2003; 101: 1319–1332.Google Scholar
Rai, R, Cohen, H, Dave, M, Regan, L. Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies. British Medical Journal 1997; 314: 253–257.CrossRefGoogle ScholarPubMed
Kutteh, WH. Antiphospholipid antibody associated recurrent pregnancy loss: treatment with heparin and low-dose aspirin is superior to low dose aspirin alone. American Journal of Obstetrics and Gynecology 1996; 174: 1584–1589.CrossRefGoogle ScholarPubMed
Izmirly, PM, Costedoat-Chalumeau, N, Pisoni, C et al. Maternal use of hydroxychloroquine is associated with a reduced risk of recurrent anti-SSA/Ro associated cardiac manifestations of neonatal lupus. Circulation 2012; 126(1): 76–82.Google Scholar
Empson, M, Lassere, M, Craig, J, Scott, J. Prevention of recurrent miscarriage for women with antiphospholipid antibody or lupus anticoagulant. Cochrane Database of Systematic Reviews 2005; (2): 002859.Google Scholar
Farquharson, RG, Quenby, S, Greaves, M. Antiphospholipid syndrome in pregnancy: a randomised controlled trial of treatment. Obstetrics and Gynecology 2002; 100: 408–413.CrossRefGoogle ScholarPubMed
Mak, A, Cheung, MWL, Cheak, AA, Ho, RC. Combination of heparin and aspirin is superior to aspirin alone in enhancing live births in patients with recurrent pregnancy loss and positive anti-phospholipid antibodies: a meta-analysis of randomized controlled trials and meta-regression. Rheumatology 2010; 49: 281–288.Google Scholar
Le Thi Huong, D, Weschler, B, Vauthier-Brouzes, D et al. The second trimester Doppler ultrasound examination is the best predictor of late pregnancy outcome in systemic lupus erythematosis and/or the antiphospholipid syndrome. Rheumatology 2006; 45: 332–338.Google Scholar
Triolo, G, Ferrante, A, Ciccia, F et al. Randomised study of subcutaneous low molecular weight heparin plus aspirin versus intravenous immunoglobulin in the treatment of recurrent fetal loss. Arthritis and Rheumatism 2003; 48: 728–731.Google Scholar
Cervera, R, Asherson, RA, Font, J et al. Chorea in the antiphospholipid syndrome: Clinical, radiologic and immunologic characteristics of 50 patients from our clinics and recent literature. Medicine 1997; 76(3): 203–212.CrossRefGoogle ScholarPubMed
Gris, JC, Bouvier, S, Molinari, N et al. Comparative incidence of a first thrombotic event in purely obstetric antiphospholipid syndrome with pregnancy loss: the NOH-APS observational study. Blood 2012; 119(11): 2624–2632.Google Scholar
Boffa, MC, Lachassine, E. Infant perinatal thrombosis and antiphospholipid antibodies: a review. Lupus 2007; 16: 634–641.Google Scholar

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