Molecular Oncology: Causes of Cancer and Targets for Treatment

doi:10.1017/CBO9781139046947

The genomic era has allowed enormous strides in our understanding of the molecular changes that underlie malignant transformation. Mutations have been discovered that are critical drivers of large cross-sections of human cancers. These discoveries have allowed us to find drugs that target these drivers and make important strides in treatment. Genomics and high-throughput technologies have illuminated the complexity of cancer and the facility with which cancers adapt during their natural history. The field is evolving rapidly with new discoveries and new drugs reported monthly. This book is a timely foundation for understanding in context the origins of molecular oncology and its future directions. The content reviews available technologies for the analysis of cancer tissues and genes; summaries of key oncogenic pathways from a molecular perspective; the technologies, pathways and targeted therapies of a wide range of human malignancies; and new pharmacologic therapies that have a common mechanistic target.

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Page 2 of 4

Contents

23 - Aurora kinases in cancer: an opportunity for targeted therapy
pp 278-292
- By Vikas Sehdev, Department of Surgery and Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA, Altaf A. Dar, California Paciic Medical Center Research Institute, San Francisco, CA, USA, Wael El-Rifai, Department of Surgery and Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA
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24 - 14-3-3 proteins in cancer
pp 293-304
- By Alexandra K. Gardino, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA, Michael B. Yaffe, David H. Koch Institute for Integrative Cancer Research and Department of Biological Engineering,Massachusetts Institute of Technology, Cambridge, MA, USA
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25 - STAT signaling as a molecular target for cancer therapy
pp 305-312
- By Hua Yu, Beckham Research Institute, City of Hope, Duarte, CA, USA, Richard Jove, Beckham Research Institute, City of Hope, Duarte, CA, USA
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26 - The MYC oncogene family in human cancer
pp 313-318
- By Michael D. Cole, Departments of Pharmacology and Genetics, Dartmouth Medical School, Norris Cotton Cancer Center, Lebanon, NH, USA
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27 - Jun proteins and AP-1 in tumorigenesis
pp 319-327
- By Shira Anzi, Department of Developmental Biology and Cancer Research, IMRIC, he Hebrew University - Hadassah Medical School, Jerusalem, Israel, Eitan Shaulian, Department of Biochemistry and Molecular Biology, IMRIC, The Hebrew University - Hadassah Medical School, Jerusalem, Israel
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28 - Forkhead box proteins: the tuning forks in cancer development and treatment
pp 328-335
- By Eric W.-F. Lam, Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, London, UK, Kyle W. Muir, Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, London, UK, Chuay-Yeng Koo, Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, London, UK
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29 - NF-κB and cancer
pp 336-352
- By Willscott E. Naugler, Oregon Health and Sciences University, Department of Medicine, Division of GI and Hepatology, Portland, OR, USA, Michael Karin, Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Pathology, Moores Cancer Center, UCSD School of Medicine, La Jolla, CA, USA
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Part 2.2 - Molecular pathways underlying carcinogenesis: apoptosis
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30 - Apoptosis: the extrinsic pathway
pp 353-366
- By Xinchen Teng, Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, USA, J. Marie Hardwick, Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, USA
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31 - Apoptosis: the intrinsic pathway
pp 367-377
- By Jody White, Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA, USA
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Part 2.3 - Molecular pathways underlying carcinogenesis: nuclear receptors
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32 - Androgens and the androgen receptor (AR)
pp 378-391
- By Nicole L. Moore, Dame Roma Mitchell Cancer Research Laboratories, Adelaide University/Hanson Institute, Adelaide, South Australia, Margaret M. Centenera, Dame Roma Mitchell Cancer Research Laboratories, Adelaide University/Hanson Institute, Adelaide, South Australia, Lisa M. Butler, Dame Roma Mitchell Cancer Research Laboratories, Adelaide University/Hanson Institute, Adelaide, South Australia, Theresa E. Hickey, Dame Roma Mitchell Cancer Research Laboratories, Adelaide University/Hanson Institute, Adelaide, South Australia, Wayne D. Tilley, Dame Roma Mitchell Cancer Research Laboratories, Adelaide University/Hanson Institute, Adelaide, South Australia
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33 - Emerging roles of peroxisome proliferator-activated receptor gamma in cancer
pp 392-402
- By Chenguang Wang, Department of Stem Cell Biology and Regenerative Medicine, Kimmel Cancer Center, Thomas Jeferson University, Philadelphia, PA, USA, Xuemin Zhang, State Key Laboratory of Proteomics, Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing, China, Lifeng Tian, Department of Cancer Biology, Kimmel Cancer Center, Thomas Jeferson University, Philadelphia, PA, USA, Richard G. Pestell, Department of Cancer Biology, Kimmel Cancer Center, Thomas Jeferson University, Philadelphia, PA, USA
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Part 2.4 - Molecular pathways underlying carcinogenesis: DNA repair
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34 - The ATM-mediated DNA-damage response
pp 403-422
- By Yosef Shiloh, The David and Inez Myers Laboratory for Genetic Research, Department of Human Molecular Genetics and Biochemistry, Sackler School ofMedicine, Tel Aviv University, Tel Aviv, Israel
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35 - Werner syndrome: association of premature aging and cancer predisposition
pp 423-433
- By Byungchan Ahn, Department of Life Sciences, University of Ulsan, Ulsan, Korea, Tinna Stevnsner, Danish Centre for Molecular Gerontology and Danish Aging Research Center, University of Aarhus, Department of Molecular Biology, Denmark, Vilhelm A. Bohr, Laboratory of Molecular Gerontology, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD, USA
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36 - Hereditary disorders of DNA repair and DNA damage tolerance that predispose to neoplastic transformation
pp 434-441
- By Errol C. Friedberg, Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA, Roger A. Schultz, Signature Genomics, Spokane,WA, USA
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37 - Telomerase: target for cancer treatment
pp 442-451
- By Jerry W. Shay, University of Texas Southwestern Medical Center, Department of Cell Biology, Dallas, TX, USA, Woodring E. Wright, University of Texas Southwestern Medical Center, Department of Cell Biology, Dallas, TX, USA
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Part 2.5 - Molecular pathways underlying carcinogenesis: cell cycle
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38 - Cell cycle: mechanisms of control and dysregulation in cancer
pp 452-464
- By Erik S. Knudsen, Department of Pathology, UT Southwestern Medical Center, Dallas, TX, USA, Ryan J. Bourgo, Kimmel Cancer Center, Department of Cancer Biology, Thomas Jeferson University, Philadelphia, PA, USA, Elizabeth L. Gosnell, Kimmel Cancer Center, Department of Cancer Biology, Thomas Jeferson University, Philadelphia, PA, USA, Jeffry L. Dean, Kimmel Cancer Center, Department of Cancer Biology, Thomas Jeferson University, Philadelphia, PA, USA, A. Kathleen McClendon, Kimmel Cancer Center, Department of Cancer Biology, Thomas Jeferson University, Philadelphia, PA, USA
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39 - DNA-damage-induced apoptosis
pp 465-472
- By Shun J. Lee, Division of Hematology-Oncology, Department of Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA, Benjamin F. O’Connor, Division of Hematology-Oncology, Department of Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA, Scott A. Stuart, Division of Hematology-Oncology, Department of Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA, Jean Y. J. Wang, Division of Hematology-Oncology, Department of Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA
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Part 2.6 - Molecular pathways underlying carcinogenesis: other pathways
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40 - The ubiquitin/proteasome pathway in neoplasia
pp 473-480
- By Robert C. A. M. van Waardenburg, Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL, USA, Mary-Ann Bjornsti, Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham AL, USA
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41 - Small silencing non-coding RNAs: cancer connections and significance
pp 481-496
- By Milena S. Nicoloso, RNA Interference and Non-coding RNA Center and the Department of Experimental herapeutics, University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA, George A. Calin, RNA Interference and Non-coding RNA Center and the Department of Experimental herapeutics, University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA
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Part 3.1 - Molecular pathology: carcinomas
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42 - Head and neck cancer
pp 497-505
- By Kelly Quesnelle, University of Pittsburgh Medical Center, Pittsburgh, PA, USA, Jennifer Grandis, University of Pittsburgh Medical Center, Pittsburgh, PA, USA, Karl Munger, Brigham andWomen’s Hospital, Harvard Medical School, Boston, MA, USA, Marshall R. Posner, Mount Sinai Medical Center, Tisch Cancer Institute, Icahn School of Medicine, New York, NY, USA
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43 - Lung cancer
pp 506-525
- By Jill E. Larsen, Hamon Center for herapeutic Oncology Research, Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA, John D. Minna, Hamon Center for herapeutic Oncology Research, Simmons Cancer Center University of Texas Southwestern Medical Center, Dallas, TX, USA
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44 - Esophageal cancer
pp 526-531
- By DuyKhanh P. Ceppa, Division ofhoracic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA, Thomas A. D’Amico, Division of horacic Surgery, Duke University Health System, Durham, NC, USA
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45 - Gastric cancer
pp 532-541
- By Yoshiaki Ito, Cancer Science Institute, National University of Singapore, Center for Translational Medicine, Singapore, Khay Guan Yeoh, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore
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46 - Small-bowel tumors: molecular mechanisms and targeted therapy
pp 542-546
- By Allan D. Spigelman, UNSW St Vincent’s Clinical School, Cancer Services, St Vincent’s & Mater Health, Sydney, Hereditary Cancer Clinic, St Vincent’s Hospital, he Kinghorn Cancer Centre, Sydney, NSW, Australia, Janindra Warusavitarne, Department of Surgery, St Mark’s Hospital, Harrow, Middlesex, UK
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Molecular Oncology

Causes of Cancer and Targets for Treatment

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