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Chapter 19 - The Role of Heparin and Aspirin to Aid Implantation

Published online by Cambridge University Press:  07 January 2019

Gabor Kovacs
Affiliation:
Monash IVF, Victoria
Lois Salamonsen
Affiliation:
Monash University, Victoria
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Publisher: Cambridge University Press
Print publication year: 2019

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References

Linhardt, RJ, Wang, HM Ampofo, SA. New methodologies in heparin structure analysis and the generation of LMW heparins. Advances in Experimental Medicine and Biology 1992;313:3747.Google Scholar
Rai, R, Cohen, H, Dave, M. et al. Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipids antibodies (or antiphospholipid antibodies). Br Med J 1997;314:253257.Google Scholar
Buckingham, KL, Chamley, LW. A critical assessment of the role of antiphospholipid antibodies in infertility. J Reprod Immunol 2009;80:132145.CrossRefGoogle ScholarPubMed
Chighizola, CB, De Jesus, GR. Antiphospholipid antibodies and infertility. Lupus 2014;23:12321238.Google Scholar
Di Simone, N, Meroni, PL, de Papa, N et al. Antiphospholipid antibodies affect trophoblast Gonadotrophins secretion and invasiveness by binding directly and through adhered beta2-glycoprotein I. Arthritis & Rheumatism 2000;43:140150.3.0.CO;2-P>CrossRefGoogle ScholarPubMed
Azem, F, Many, A, Ben Ami, I et al. Increased rates of thrombophilia in women with repeated IVF failures. Human Reproduction 2004;19:368370.Google Scholar
Urman, B, Ata, B, Yakin, K et al. Luteal phase empirical low molecular weight heparin administration in patients with failed ICSI embryo transfer cycles: a randomized open-labelled pilot trial. Hum Reprod 2009;24:16401647.CrossRefGoogle Scholar
Fluhr, H, Spratte, J, Ehrhardt, J et al. Heparin and low-molecular-weight heparins modulate the decidualization of human endometrial stromal cells. Fertil Steril 2010;93:25812587.Google Scholar
Wilcox, AJ, Baird, DD, Weinberg, CR. Time of implantation of the conceptus and loss of pregnancy. N Engl J Med 1999;340:1796–99.Google Scholar
Seshadri, S, Sunkara, SK, Khalaf, Y, El-Toukhy, T, Hamoda, H. Effect of heparin on the outcome of IVF treatment: a systematic review and meta-analysis. Reproductive Biomedicine Online 2012;25:572584.CrossRefGoogle ScholarPubMed
Akhtar, MA, Sur, S, Raine-Fenning, N et al. Heparin for assisted reproduction. Cochrane Database of Systematic Reviews 2013;8:CD009452.Google Scholar
Potdar, N, Gelbaya, TA, Konje, JC, Nardo, LG. Adjunct low-molecular-weight-heparin to improve live birth rate after recurrent implantation failure: a systematic review and meta-analysis. Human Reproduction Update 2013;19:674684.Google Scholar
Hornstein, MD, Davis, OK, Massey, JB, Paulson, RJ, Collins, JA. Antiphospholipid antibodies and in vitro fertilization success. A meta analysis. Fertil Steril 2000;73:330333.CrossRefGoogle ScholarPubMed
RCOG green top guideline no. 17.Google Scholar
Fishel, S, Baker, D, Greer, I. LMWH in IVF-biomarkers and benefits. Thrombosis Research 2017;151(suppl1):S65S69.Google Scholar
Collaborative low dose aspirin study in pregnancy, collaborative group CLASP; a randomised trial of low dose aspirin for the prevention and treatment of pre-eclampsia among 9364 pregnant women. Lancet 1994;343:619629.CrossRefGoogle Scholar
Empson, MB, Lassere, M, Craig, JC, Scott, JR. Cochrane database of systematic reviews 2005;2:CD002859Google Scholar
Gelbaya, TA, Kyrgiou, M, Li, TC, Stern, C, Nardo, LG. Low dose aspirin for in vitro fertilization: a systematic review and meta-analysis. Hum Reprod Update. 2007 Jul-Aug;13(4):35764.CrossRefGoogle Scholar
Siristatidis, CS, Basios, G, Pergialiotis, V, Vogiatzi, P. Cochrane Database of Systematic Reviews 2016;11:CD004832.Google Scholar

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