G Protein-Coupled Receptors: Structure, Signaling, and Physiology

doi:10.1017/CBO9780511760334

G Protein-Coupled Receptors

Structure, Signaling, and Physiology

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Ehrlich, Aliza T. Furuyashiki, Tomoyuki Kitaoka, Shiho Kakizuka, Akira and Narumiya, Shuh 2013. Prostaglandin E Receptor EP1 Forms a Complex with Dopamine D1 Receptor and Directs D1-Induced cAMP Production to Adenylyl Cyclase 7 through Mobilizing GβγSubunits in Human Embryonic Kidney 293T Cells. Molecular Pharmacology, Vol. 84, Issue. 3, p. 476.

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Edited by Sandra Siehler, Novartis Institute for Biomedical Research, Graeme Milligan, University of Glasgow

Publisher:: Cambridge University Press
Online publication date:: June 2012
Print publication year:: 2010
Online ISBN:: 9780511760334
DOI:: https://doi.org/10.1017/CBO9780511760334

Subjects:: Life Sciences, Pharmacology, Molecular Biology, Biochemistry, and Structural Biology

146.00 (GBP)

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Provides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs). Recent advances include the first mammalian non-rhodopsin GPCR structures and reconstitution of purified GPCRs into membrane discs for defined studies, novel signaling features including oligomerization, and advances in understanding the complex ligand pharmacology and physiology of GPCRs, in new assay technologies and drug targeting. The authors take time to detail the importance of the pathophysiological function and drug targeting of GPCRs, specifically β-adrenoceptors in cardiovascular and respiratory diseases, metabotropic glutamate receptors in CNS disorders, S1P receptors in the immune system, and Wnt/Frizzled receptors in osteoporosis. This book will be invaluable to researchers and graduate students in academia and industry who are interested in the GPCR field.

"The editors of G Protein-Coupled Receptors: Structure, Signaling, and Physiology successfully synthesize decades of research into a well-organized reference textbook. The layout of this text is one of its best features... the strengths of this text would be most appreciated by the structural pharmacologist hoping to gain a comprehensive overview of GPCR biology. The well-outlined chapters balance the abundance and often overwhelming supply of references, while the simple figures and summary tables provide valuable information for the GPCR novice."
Alexandra Teixeira, Yale Journal of Biology and Medicine

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G Protein-Coupled Receptors

Structure, Signaling, and Physiology

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