Book contents
- Frontmatter
- Contents
- List of contributors
- Preface: Focus on the serotonin transporter
- 1 Presynaptic adaptive responses to constitutive versus adult pharmacologic inhibition of serotonin uptake
- 2 Cellular and molecular alterations in animal models of serotonin transporter disruption: a comparison between developmental and adult stages
- 3 Developmental roles for the serotonin transporter
- 4 SERT models of emotional dysregulation
- 5 The serotonin transporter and animal models of depression
- 6 The serotonin transporter knock-out rat: a review
- 7 Wistar–Zagreb 5HT rats: a rodent model with constitutional upregulation/downregulation of serotonin transporter
- 8 The role of the serotonin transporter in reward mechanisms
- 9 Modeling SERT × BDNF interactions in brain disorders: single BDNF gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities in serotonin transporter knock-out mice
- 10 Primate models in serotonin transporter research
- 11 The role of serotonin transporter in modeling psychiatric disorders: focus on depression, emotion regulation, and the social brain
- Index
- Plate section
- References
8 - The role of the serotonin transporter in reward mechanisms
Published online by Cambridge University Press: 06 July 2010
- Frontmatter
- Contents
- List of contributors
- Preface: Focus on the serotonin transporter
- 1 Presynaptic adaptive responses to constitutive versus adult pharmacologic inhibition of serotonin uptake
- 2 Cellular and molecular alterations in animal models of serotonin transporter disruption: a comparison between developmental and adult stages
- 3 Developmental roles for the serotonin transporter
- 4 SERT models of emotional dysregulation
- 5 The serotonin transporter and animal models of depression
- 6 The serotonin transporter knock-out rat: a review
- 7 Wistar–Zagreb 5HT rats: a rodent model with constitutional upregulation/downregulation of serotonin transporter
- 8 The role of the serotonin transporter in reward mechanisms
- 9 Modeling SERT × BDNF interactions in brain disorders: single BDNF gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities in serotonin transporter knock-out mice
- 10 Primate models in serotonin transporter research
- 11 The role of serotonin transporter in modeling psychiatric disorders: focus on depression, emotion regulation, and the social brain
- Index
- Plate section
- References
Summary
ABSTRACT
In recent years, gene knock-out studies have greatly expanded understanding of the molecular basis of drug reward and drug addiction. One of the consequences of these studies has been to produce a more pluralistic view of the underlying neurochemical mechanisms that mediate drug reward after the development of a strongly dopamine-centered view in the 1980s. This is not to say that dopamine does not have a central role in drug reward and drug addiction, but rather a fuller examination of these mechanisms involves the complex neurocircuitry of which dopamine systems are a part. This view is not new, but has been expressed from a variety of perspectives. Gene knock-out studies have indicated a particular approach to examining the nature of interactions between different parts of this circuitry. This chapter will focus on the role of serotonin, and in particular the serotonin transporter (SERT), in drug reward. This more pluralistic perspective became apparent in gene knock-out studies of the rewarding effects of drugs of abuse which demonstrated that deletion of the dopamine transporter (DAT) did not eliminate the rewarding effects of cocaine, and subsequent findings that implicated a critical role of SERT in a variety of circumstances. These studies also validated the central role of dopamine in drug reward, and consequently the role of SERT must be considered largely from the point of view of interactions with dopamine systems.
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- Experimental Models in Serotonin Transporter Research , pp. 244 - 269Publisher: Cambridge University PressPrint publication year: 2010