Skip to main content Accessibility help
×
Hostname: page-component-586b7cd67f-t7czq Total loading time: 0 Render date: 2024-11-22T19:20:35.795Z Has data issue: false hasContentIssue false

Chapter 25 - Menopause and Hormone Replacement Therapy

from Section 5 - Post-Reproductive Care

Published online by Cambridge University Press:  24 November 2021

Tahir Mahmood
Affiliation:
Victoria Hospital, Kirkcaldy
Charles Savona-Ventura
Affiliation:
University of Malta, Malta
Ioannis Messinis
Affiliation:
University of Thessaly, Greece
Sambit Mukhopadhyay
Affiliation:
Norfolk & Norwich University Hospital, UK
Get access

Summary

Menopause is defined as the permanent cessation of menstruation that occurs after the loss of ovarian follicular function. The name is derived from the Greek words menos meaning month and pausis (cessation). It marks the end of the reproductive lifespan and is accompanied by changes within the neuroendocrine system that manifest in clinical symptoms classically associated with menopause. Menopause can occur naturally (spontaneously) or be induced through a medical intervention (surgery, chemotherapy or pelvic radiation therapy).

Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2021

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Kok, HS, van Asselt, KM, van der Schouw, YT, Peeters, PH, Wijmenga, C. Genetic studies to identify genes underlying menopausal age. Hum Reprod Update 2005;11:483493.Google Scholar
Mishra, GD, Pandeya, N, Dobson, AJ, et al. Early menarche, nulliparity and the risk for premature and early natural menopause. Hum Reprod 2017;32:679686.Google Scholar
Soules, MR, Sherman, S, Parrott, E, et al. Executive summary: stages of reproductive aging workshop (STRAW). Climacteric 2001;4:267272.Google Scholar
Durlinger, AL, Kramer, P, Karels, B, et al. Control of primordial follicle recruitment by anti-Müllerian hormone in the mouse ovary. Endocrinology 1999;140:57895796.Google Scholar
Avis, NE, Crawford, SL, Greendale, G, et al. Duration of menopausal vasomotor symptoms over the menopause transition. JAMA Intern Med 2015;175:531539.Google Scholar
Muka, T, Oliver-Williams, C, Colpani, V, et al. Association of vasomotor and other menopausal symptoms with risk of cardiovascular disease: a systematic review and meta-analysis. PLoS One 2016;11:e0157417.CrossRefGoogle ScholarPubMed
Portman, DJ, Gass, ML. Genitourinary syndrome of menopause: new terminology for vulvovaginal atrophy from the International Society for the Study of Women’s Sexual Health and the North American Menopause Society. Climacteric 2014;17:557563.CrossRefGoogle Scholar
Kanis, JA. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: synopsis of a WHO report. Osteoporos Int 1994;4:368381.Google Scholar
Thurston, RC, Joffe, H. Vasomotor symptoms and menopause: findings from the Study of Women’s Health across the Nation. Obstet Gynecol Clin 2011;38:489501.CrossRefGoogle ScholarPubMed
Anderson, GL, Limacher, M, Assaf, AR, et al. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women’s Health Initiative randomized controlled trial. JAMA 2004;291:17011712.Google Scholar
Collaborative Group on Epidemiological Studies of Ovarian Cancer. Menopausal hormone use and ovarian cancer risk: individual participant meta-analysis of 52 epidemiological studies. Lancet 2015;385:18351842.Google Scholar
Boardman, HM, Hartley, L, Eisinga, A, et al. Hormone therapy for preventing cardiovascular disease in post‐menopausal women. Cochrane Database Syst Rev 2015;3:CD002229.Google Scholar
Pandya, KJ, Raubertas, RF, Flynn, PJ, et al. Oral clonidine in postmenopausal patients with breast cancer experiencing tamoxifen-induced hot flashes: a University of Rochester Cancer Center Community Clinical Oncology Program study. Ann Intern Med 2000;132:788793.CrossRefGoogle ScholarPubMed
Evans, ML, Pritts, E, Vittinghoff, E, et al. Management of postmenopausal hot flushes with venlafaxine hydrochloride: a randomized, controlled trial. Obstet Gynecol 2005;105:161166.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×